A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease. (Q36094049)

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English	A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease.	scientific article

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29 January 2020

A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease (English)

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29 January 2020

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rheumatoid arthritis

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29 January 2020

Catharien M. Hilkens

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29 January 2020

David Alan Young

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29 January 2020

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Sarah Richardson

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29 January 2020

Gillian Wilson

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24 April 2012

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29 January 2020

Annals of the Rheumatic Diseases

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1374-1381

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8

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29 January 2020

State-of-the-art: rheumatoid arthritis

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A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

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A genomic approach to human autoimmune diseases

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2 October 2017

Kinase inhibitors: a new approach to rheumatoid arthritis treatment

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2 October 2017

Self-regulation of Stat3 activity coordinates cell-cycle progression and neural crest specification

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MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

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2 October 2017

Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis.

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2 October 2017

Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies

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2 October 2017

Interleukin-6 as a key player in systemic inflammation and joint destruction.

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2 October 2017

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

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2 October 2017

Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study.

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2 October 2017

STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production

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Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway

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2 October 2017

Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis

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2 October 2017

Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification

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2 October 2017

BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription

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2 October 2017

Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer

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2 October 2017

Adjusting batch effects in microarray expression data using empirical Bayes methods

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2 October 2017

The RIN: an RNA integrity number for assigning integrity values to RNA measurements

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2 October 2017

EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).

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2 October 2017

Peripheral blood gene expression profiling in rheumatoid arthritis.

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2 October 2017

Series introduction. JAK-STAT signaling in human disease

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

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2 October 2017

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

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2 October 2017

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2 October 2017

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23 September 2018

Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis

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23 September 2018

Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study

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Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: Moving toward individualized treatment decision-making

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21 October 2018

A key role for G-CSF-induced neutrophil production and trafficking during inflammatory arthritis

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https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The clinical utility of a rule for predicting rheumatoid arthritis in patients with early undifferentiated arthritis: Comment on the article by van der Helm-van Mil et al

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profiling in autoantibody-positive patients with arthralgia predicts development of arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22532634

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1136/ANNRHEUMDIS-2011-200968

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

1 reference

Europe PubMed Central

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29 January 2020

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