XRN2 Links Transcription Termination to DNA Damage and Replication Stress (Q36082634)

12 August 2017

XRN2 Links Transcription Termination to DNA Damage and Replication Stress (English)

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12 August 2017

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1

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10 June 2020

James L. Manley

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10 June 2020

author name string

Patricia Richard

2

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10 June 2020

Praveen L Patidar

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10 June 2020

Edward A Motea

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10 June 2020

Tuyen T Dang

5

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10 June 2020

David A Boothman

7

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10 June 2020

publication date

20 July 2016

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12 August 2017

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10 June 2020

volume

12

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10 June 2020

issue

7

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10 June 2020

page(s)

e1006107

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Creative Commons Attribution 4.0 International

10 June 2020

copyright license

start time

20 July 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Effects of Transcription Elongation Rate and Xrn2 Exonuclease Activity on RNA Polymerase II Termination Suggest Widespread Kinetic Competition.

1 reference

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Repair Pathway Choices and Consequences at the Double-Strand Break

2 October 2017

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2 October 2017

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2 October 2017

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Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids

2 October 2017

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Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

2 October 2017

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BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair

2 October 2017

1 reference

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Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

2 October 2017

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R-loops induce repressive chromatin marks over mammalian gene terminators

2 October 2017

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Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

The causes of replication stress and their consequences on genome stability and cell fate.

2 October 2017

1 reference

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Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

2 October 2017

1 reference

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Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.

2 October 2017

1 reference

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A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage

2 October 2017

1 reference

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The RNA exosome and proteasome: common principles of degradation control

2 October 2017

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Causes of genome instability

2 October 2017

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GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

2 October 2017

1 reference

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DNA repair mechanisms in dividing and non-dividing cells

2 October 2017

1 reference

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Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Transcription-replication encounters, consequences and genomic instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

2 October 2017

1 reference

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R loops: from transcription byproducts to threats to genome stability

2 October 2017

1 reference

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Transcription as a source of genome instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

RNase H and multiple RNA biogenesis factors cooperate to prevent RNA:DNA hybrids from generating genome instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes

2 October 2017

1 reference

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Ending the message: poly(A) signals then and now

2 October 2017

1 reference

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Choosing the right cell line for breast cancer research

2 October 2017

1 reference

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Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

2 October 2017

1 reference

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Hallmarks of Cancer: The Next Generation

2 October 2017

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Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

2 October 2017

1 reference

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Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response

2 October 2017

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Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

2 October 2017

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Transcription termination by nuclear RNA polymerases

2 October 2017

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Human CtIP promotes DNA end resection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Distinct pathways for snoRNA and mRNA termination

2 October 2017

1 reference

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An antibody-based microarray assay for small RNA detection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

The DNA damage response: putting checkpoints in perspective

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

RRP6/EXOSC10 is required for the repair of DNA double-strand breaks by homologous recombination.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

Identification of the Polypyrimidine Tract Binding Protein-associated Splicing Factor·p54(nrb) Complex as a Candidate DNA Double-strand Break Rejoining Factor

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4954731

An evolutionarily conserved target motif for immunoglobulin class-switch recombination

23 September 2018

1 reference

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Interdependence between Transcription and mRNP Processing and Export, and Its Impact on Genetic Stability

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27437695

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27437695

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27437695

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PGEN.1006107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27437695%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27437695%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference