Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease (Q36081561)

12 August 2017

Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease (English)

1 reference

12 August 2017

0 references

José Vicente Llorens

3

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María D. Moltó

object named as

María Dolores Moltó

8

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Lucia Gutierrez

object named as

Lucía Gutiérrez

5

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author name string

Sirena Soriano

1

1 reference

12 August 2017

Pablo Calap-Quintana

2

1 reference

12 August 2017

Ismael Al-Ramahi

4

1 reference

12 August 2017

María José Martínez-Sebastián

6

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12 August 2017

Juan Botas

7

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12 August 2017

language of work or name

English

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publication date

19 July 2016

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12 August 2017

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12 August 2017

11

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12 August 2017

7

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12 August 2017

e0159209

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Creative Commons Attribution 4.0 International

12 August 2017

start time

19 July 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia

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The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

2 October 2017

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Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review.

2 October 2017

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Friedreich ataxia: metal dysmetabolism in dorsal root ganglia

2 October 2017

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The relevance of metals in the pathophysiology of neurodegeneration, pathological considerations

2 October 2017

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Neurodegeneration in Friedreich's ataxia: from defective frataxin to oxidative stress

2 October 2017

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RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1

2 October 2017

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Iron absorption in Drosophila melanogaster

2 October 2017

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ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading

2 October 2017

1 reference

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Clinical features of Friedreich ataxia

2 October 2017

1 reference

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Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates aβ pathology in a Drosophila model of Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Friedreich's ataxia causes redistribution of iron, copper, and zinc in the dentate nucleus

2 October 2017

1 reference

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Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans

2 October 2017

1 reference

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The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1)

2 October 2017

1 reference

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Two to tango: regulation of Mammalian iron metabolism

2 October 2017

1 reference

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Understanding the molecular mechanisms of Friedreich's ataxia to develop therapeutic approaches.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Long intronic GAA*TTC repeats induce epigenetic changes and reporter gene silencing in a molecular model of Friedreich ataxia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Cell functions impaired by frataxin deficiency are restored by drug-mediated iron relocation

2 October 2017

1 reference

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The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation

2 October 2017

1 reference

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Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

DNA triplexes and Friedreich ataxia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Hydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Autosomal recessive cerebellar ataxias

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Copper homeostasis in eukaryotes: teetering on a tightrope

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Insect iron binding proteins: insights from the genomes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Peptidomic and proteomic analyses of the systemic immune response of Drosophila

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Antioxidant role of metallothioneins: a comparative overview

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Drosophila melanogaster transferrin. Cloning, deduced protein sequence, expression during the life cycle, gene localization and up-regulation on bacterial infection

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Iron-regulatory protein-1 (IRP-1) is highly conserved in two invertebrate species--characterization of IRP-1 homologues in Drosophila melanogaster and Caenorhabditis elegans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Phenotype correlation and intergenerational dynamics of the Friedreich ataxia GAA trinucleotide repeat

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Pathology of the Heart in Friedreich's Ataxia: Review of the Literature and Report of One Case

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Deferiprone in Friedreich ataxia: a 6-month randomized controlled trial.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Deferiprone and idebenone rescue frataxin depletion phenotypes in a Drosophila model of Friedreich's ataxia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Altered lipid metabolism in a Drosophila model of Friedreich's ataxia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Selective iron chelation in Friedreich ataxia: biologic and clinical implications

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Causative role of oxidative stress in a Drosophila model of Friedreich ataxia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Prooxidative effect of copper--metallothionein in the acute cytotoxicity of hydrogen peroxide in Ehrlich ascites tumour cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

Increased iron in the dentate nucleus of patients with Friedrich's ataxia

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4951068

The cardiomyopathy of Friedreich's ataxia morphological observations in 3 cases

23 September 2018

1 reference

12 December 2020

Production of hydroxyl radicals by copper-containing metallothionein: roles as prooxidant

1 reference

12 December 2020

Bifunctional anti/prooxidant potential of metallothionenin: redox signaling of copper binding and release

1 reference

12 December 2020

Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals

1 reference

12 December 2020

Clinical, biochemical and molecular genetic correlations in Friedreich's ataxia

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0159209

Identifiers

DOI

1 reference

12 August 2017

0 references

1 reference

12 August 2017

PubMed publication ID

27433942

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