Modulation of apoptosis as a target for liver disease (Q36066290)

12 August 2017

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title

Modulation of apoptosis as a target for liver disease (English)

1 reference

12 August 2017

Sören T Eichhorst

1

1 reference

PubMed ID

15757484

12 August 2017

language of work or name

English

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publication date

1 February 2005

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Expert Opinion on Therapeutic Targets

12 August 2017

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12 August 2017

9

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12 August 2017

1

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12 August 2017

83-99

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Pathways of apoptotic and non-apoptotic death in tumour cells

12 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Death and anti-death: tumour resistance to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cellular FLICE-inhibitory protein: an attractive therapeutic target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Caspase 8 small interfering RNA prevents acute liver failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Apo2L/TRAIL and its death and decoy receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

TNF-R1 signaling: a beautiful pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

How cells read TGF-beta signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Role of transforming growth factor beta in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Role of transforming growth factor beta 1 on hepatic regeneration and apoptosis in liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Transforming growth factor-beta(1) induces apoptosis in rat FaO hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700-kd apoptosome caspase-processing complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The pathophysiology of mitochondrial cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cell death: critical control points

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Apoptosis in liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Functional significance of the perforin/granzyme cell death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cathepsins as effector proteases in hepatocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Noncaspase proteases in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-alpha production by Kupffer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Neurokinin-1 receptor antagonists protect mice from CD95- and tumor necrosis factor-alpha-mediated apoptotic liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Critical role of CXC chemokines in endotoxemic liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Mechanisms of acetaldehyde-mediated growth inhibition: delayed cell cycle progression and induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Lymphocyte-mediated liver injury in alcohol-related hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Lymphocyte recruitment to the liver in alcoholic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Aetiology and pathogenesis of alcoholic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cytokines and the molecular mechanisms of alcoholic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cytotoxicity of millimolar concentrations of ethanol on HepG2 human tumor cell line compared to normal rat hepatocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Ethanol-induced apoptosis in hepatoma cells proceeds via intracellular Ca(2+) elevation, activation of TLCK-sensitive proteases, and cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Glutathione dependence of caspase-8 activation at the death-inducing signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cold-induced apoptosis of rat liver cells in University of Wisconsin solution: the central role of chelatable iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Molecular bases of cellular iron toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Iron-induced mitochondrial permeability transition in cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis C virus NS5A as a potential viral Bcl-2 homologue interacts with Bax and inhibits apoptosis in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The hepatitis B virus HBx protein inhibits caspase 3 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Suppression of apoptotic cell death by hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis C virus core protein inhibits apoptosis via enhanced Bcl-xL expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis C virus core protein does not inhibit apoptosis in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatitis C virus protein expression induces apoptosis in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The nature of piecemeal necrosis in chronic active hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

An NO derivative of ursodeoxycholic acid protects against Fas-mediated liver injury by inhibiting caspase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Transforming growth factor-beta1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The caspase inhibitor IDN-6556 prevents caspase activation and apoptosis in sinusoidal endothelial cells during liver preservation injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Platelets induce sinusoidal endothelial cell apoptosis upon reperfusion of the cold ischemic rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Extended preservation of rat liver graft by induction of heme oxygenase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Atrial natriuretic peptide preconditioning protects against hepatic preservation injury by attenuating necrotic and apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatic injury induced by bile salts: correlation between biochemical and morphological events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cholestasis increases tumor necrosis factor-related apoptotis-inducing ligand (TRAIL)-R2/DR5 expression and sensitizes the liver to TRAIL-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Mechanisms of Human Hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Developmental context determines latency of MYC-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Quantitative analysis of apoptosis-related gene expression in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Expression of survivin messenger RNA correlates with poor prognosis in patients with hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Soluble Fas/APO-1 in tumor cells: a potential regulator of apoptosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

Cholestasis in Rats induced by Taurolithocholate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.9.1.83

21 January 2018

Identifiers

DOI

10.1517/14728222.9.1.83

1 reference

12 August 2017

1 reference

PubMed ID

15757484