Pathogenesis-related mutations in the T-loops of human mitochondrial tRNAs affect 3' end processing and tRNA structure (Q36062606)

11 August 2017

Pathogenesis-related mutations in the T-loops of human mitochondrial tRNAs affect 3' end processing and tRNA structure (English)

1 reference

11 August 2017

Louis Levinger

1

1 reference

PMCID

3384583

11 August 2017

Dmitri Serjanov

series ordinal

2

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11 August 2017

1 March 2012

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11 August 2017

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11 August 2017

9

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11 August 2017

3

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11 August 2017

283-291

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PMCID

3384583

describes a project that uses

11 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3384583/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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2 October 2017

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2 October 2017

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Impairment of mitochondrial tRNAIle processing by a novel mutation associated with chronic progressive external ophthalmoplegia

2 October 2017

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2 October 2017

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2 October 2017

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Effect of changes in the flexible arm on tRNase Z processing kinetics

2 October 2017

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RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme

2 October 2017

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The structure of the flexible arm ofThermotoga maritimatRNase Z differs from those of homologous enzymes

2 October 2017

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2 October 2017

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Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

2 October 2017

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Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure

2 October 2017

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Mitochondrial tRNA 3' end metabolism and human disease.

2 October 2017

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The 7472insC mtDNA mutation impairs 5' and 3' processing of tRNA(Ser(UCN)).

2 October 2017

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Drosophila RNase Z processes mitochondrial and nuclear pre-tRNA 3' ends in vivo

2 October 2017

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Impact of disease-related mitochondrial mutations on tRNA structure and function

2 October 2017

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2 October 2017

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2 October 2017

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Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family

2 October 2017

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The non-Watson-Crick base pairs and their associated isostericity matrices

2 October 2017

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Assigning a function to a conserved group of proteins: the tRNA 3'-processing enzymes

2 October 2017

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2 October 2017

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In vitro 3'-end endonucleolytic processing defect in a human mitochondrial tRNA(Ser(UCN)) precursor with the U7445C substitution, which causes non-syndromic deafness

2 October 2017

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2 October 2017

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A candidate prostate cancer susceptibility gene at chromosome 17p

2 October 2017

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Search for characteristic structural features of mammalian mitochondrial tRNAs.

2 October 2017

1 reference

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A novel homoplasmic mutation in mtDNA with a single evolutionary origin as a risk factor for cardiomyopathy

2 October 2017

1 reference

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New evidence for the genomic tag hypothesis: archaeal CCA-adding enzymes and tDNA substrates

2 October 2017

1 reference

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A top-half tDNA minihelix is a good substrate for the eubacterial CCA-adding enzyme.

2 October 2017

1 reference

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tRNA punctuation model of RNA processing in human mitochondria

2 October 2017

1 reference

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Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs

2 October 2017

1 reference

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Sequence and organization of the human mitochondrial genome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae.

2 October 2017

1 reference

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tRNase Z catalysis and conserved residues on the carboxy side of the His cluster

2 October 2017

1 reference

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Mamit-tRNA, a database of mammalian mitochondrial tRNA primary and secondary structures

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

The crystal structure of the zinc phosphodiesterase from Escherichia coli provides insight into function and cooperativity of tRNase Z-family proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

Ribozyme processed tRNA transcripts with unfriendly internal promoter for T7 RNA polymerase: production and activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

Matrices of paired substitutions show the effects of tRNA D/T loop sequence on Drosophila RNase P and 3'-tRNase processing.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

Model substrates for an RNA enzyme

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384583

A pathogenesis-associated mutation in human mitochondrial tRNALeu(UUR) leads to reduced 3'-end processing and CCA addition.

27 July 2018

1 reference

Exosite modules guide substrate recognition in the ZiPD/ElaC protein family

21 January 2018

1 reference

The fission yeast Schizosaccharomyces pombe has two distinct tRNase Z(L)s encoded by two different genes and differentially targeted to the nucleus and mitochondria.

21 January 2018

1 reference

RNAi knockdown of dRNaseZ, the Drosophila homolog of ELAC2, impairs growth of mitotic and endoreplicating tissues

21 January 2018

1 reference

Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z.

21 January 2018

1 reference

Contrasting phenotypes in three patients with novel mutations in mitochondrial tRNA genes

21 January 2018

1 reference

A double mutation (G11778A and G12192A) in mitochondrial DNA associated with Leber's hereditary optic neuropathy and cardiomyopathy.

21 January 2018

1 reference

Crystal Structure of the tRNA 3′ Processing Endoribonuclease tRNase Z fromThermotoga maritima

21 January 2018

1 reference

A new point mutation at nucleotide pair 3291 of the mitochondrial tRNA(Leu(UUR)) gene in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)

21 January 2018

1 reference

12 December 2020

Mitochondrial DNA mutations in cardiomyopathy: Combination of replacements yielding cysteine residues and tRNA mutations

1 reference

12 December 2020

A new mitochondrial DNA mutation (A3288G) in the tRNALeu(UUR) gene associated with familial myopathy

1 reference

12 December 2020

Effects of conserved D/T loop substitutions in the pre-tRNA substrate on tRNase Z catalysis

1 reference

12 December 2020

A kinetic mechanism for cleavage of precursor tRNA(Asp) catalyzed by the RNA component of Bacillus subtilis ribonuclease P

1 reference

12 December 2020

Novel mutation in the mitochondrial DNA tRNA glycine gene associated with sudden unexpected death

1 reference

12 December 2020

Identifiers

DOI

10.4161/RNA.19025

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3384583