Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. (Q36058554)

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English	Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.	scientific article

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scholarly article

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Europe PubMed Central

11 August 2017

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. (English)

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Europe PubMed Central

11 August 2017

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Dimitar Efremov

object named as

Dimitar G Efremov

7

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author name string

Roberto Negro

1

1 reference

Europe PubMed Central

11 August 2017

Stefania Gobessi

2

1 reference

Europe PubMed Central

11 August 2017

Pablo G Longo

3

1 reference

Europe PubMed Central

11 August 2017

Yantao He

4

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Europe PubMed Central

11 August 2017

Zhong-Yin Zhang

5

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Europe PubMed Central

11 August 2017

Luca Laurenti

6

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Europe PubMed Central

11 August 2017

language of work or name

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publication date

8 May 2012

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Europe PubMed Central

11 August 2017

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10

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Europe PubMed Central

11 August 2017

119

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Europe PubMed Central

11 August 2017

26

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Europe PubMed Central

11 August 2017

6278-6287

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Europe PubMed Central

11 August 2017

PTPN22 1858C>T polymorphism distribution in Europe and association with rheumatoid arthritis: case-control study and meta-analysis

1 reference

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Oral protein kinase c β inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C β Inhibitor-Diabetic Retinopathy Study and the Protein Kinase C β I

1 reference

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2 October 2017

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

1 reference

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2 October 2017

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

1 reference

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2 October 2017

The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia

1 reference

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Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.

1 reference

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Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin

1 reference

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Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

1 reference

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Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

1 reference

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2 October 2017

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

1 reference

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2 October 2017

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

1 reference

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2 October 2017

Protein tyrosine phosphatases in autoimmunity.

1 reference

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2 October 2017

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

1 reference

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2 October 2017

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

ER stress is involved in B cell antigen receptor ligation-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

1 reference

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2 October 2017

Src family kinases: regulation of their activities, levels and identification of new pathways

1 reference

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2 October 2017

Identification of substrates of human protein-tyrosine phosphatase PTPN22

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Lyn tyrosine kinase: accentuating the positive and the negative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Chronic lymphocytic leukemia: revelations from the B-cell receptor.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

The function of the protein tyrosine phosphatase SHP-1 in cancer

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2 October 2017

Regulation of B-cell fate by antigen-receptor signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia

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2 October 2017

Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

2 October 2017

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27 July 2018

Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

27 July 2018

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

23 September 2018

Sotrastaurin, a novel small molecule inhibiting protein-kinase C: randomized phase II study in renal transplant recipients.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

23 September 2018

Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

23 September 2018

ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3383194

23 September 2018

V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity

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https://pubmed.ncbi.nlm.nih.gov/22569400

12 December 2020

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Antigen receptor nonresponsiveness in chronic lymphocytic leukemia B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22569400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal Syk protein level but abnormal tyrosine phosphorylation in B-CLL cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22569400

12 December 2020

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Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status

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based on heuristic

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10.1182/BLOOD-2012-01-403162

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Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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