Brain-penetrant LSD1 inhibitors can block memory consolidation. (Q36057705)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22754608%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Brain-penetrant LSD1 inhibitors can block memory consolidation (English)

1 reference

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6 February 2020

9

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6 February 2020

Debasis Patnaik

4

1 reference

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6 February 2020

Jacob M. Hooker

10

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6 February 2020

8

Marcelo A Wood

1 reference

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6 February 2020

author name string

Ramesh Neelamegam

1

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6 February 2020

Emily L Ricq

2

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6 February 2020

Melissa Malvaez

3

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6 February 2020

Stephanie Norton

5

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6 February 2020

Stephen M Carlin

6

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6 February 2020

Ian T Hill

7

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6 February 2020

publication date

18 October 2011

1 reference

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ACS Chemical Neuroscience

6 February 2020

published in

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6 February 2020

volume

3

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6 February 2020

issue

2

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6 February 2020

page(s)

120-128

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Lysine demethylases inhibitors

6 February 2020

cites work

1 reference

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2 October 2017

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Screening for lysine-specific demethylase-1 inhibitors using a label-free high-throughput mass spectrometry assay

2 October 2017

1 reference

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Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors

2 October 2017

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Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

2 October 2017

1 reference

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HDAC3 is a critical negative regulator of long-term memory formation

2 October 2017

1 reference

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Accessing protein methyltransferase and demethylase enzymology using microfluidic capillary electrophoresis

2 October 2017

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Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

2 October 2017

1 reference

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Distribution of lysine-specific demethylase 1 in the brain of rat and its response in transient global cerebral ischemia

2 October 2017

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Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2

2 October 2017

1 reference

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Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification

2 October 2017

1 reference

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Histone methylation regulates memory formation.

2 October 2017

1 reference

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Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors

2 October 2017

1 reference

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Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

2 October 2017

1 reference

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Identification of cell-active lysine specific demethylase 1-selective inhibitors

2 October 2017

1 reference

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Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

2 October 2017

1 reference

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LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

2 October 2017

1 reference

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Modulation of long-term memory for object recognition via HDAC inhibition

2 October 2017

1 reference

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A novel mammalian flavin-dependent histone demethylase

2 October 2017

1 reference

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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

2 October 2017

1 reference

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Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory

2 October 2017

1 reference

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Mechanisms involved in the regulation of histone lysine demethylases

2 October 2017

1 reference

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Transrepressive function of TLX requires the histone demethylase LSD1.

2 October 2017

1 reference

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LSD1: oxidative chemistry for multifaceted functions in chromatin regulation

2 October 2017

1 reference

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LSD1 and the chemistry of histone demethylation

2 October 2017

1 reference

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Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

2 October 2017

1 reference

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Structural basis of LSD1-CoREST selectivity in histone H3 recognition

2 October 2017

1 reference

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Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

2 October 2017

1 reference

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Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

2 October 2017

1 reference

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trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

2 October 2017

1 reference

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Chromatin modifications and their function

2 October 2017

1 reference

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Combinatorial chromatin modifications and memory storage: a code for memory?

2 October 2017

1 reference

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A mechanism-based inactivator for histone demethylase LSD1.

2 October 2017

1 reference

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Histone demethylation by a family of JmjC domain-containing proteins

2 October 2017

1 reference

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Regulation of LSD1 histone demethylase activity by its associated factors

2 October 2017

1 reference

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An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

2 October 2017

1 reference

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Epigenetic mechanisms in memory formation.

2 October 2017

1 reference

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

2 October 2017

1 reference

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A crack in histone lysine methylation.

2 October 2017

1 reference

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Coordinated histone modifications mediated by a CtBP co-repressor complex

2 October 2017

1 reference

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CoREST is an integral component of the CoREST- human histone deacetylase complex

2 October 2017

1 reference

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Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

2 October 2017

1 reference

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Signaling to chromatin through histone modifications

2 October 2017

1 reference

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The language of covalent histone modifications

2 October 2017

1 reference

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Memory--a century of consolidation

2 October 2017

1 reference

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Monoamine oxidase inhibitors: Nature of their interaction with rabbit pancreatic islets to alter insulin secretion

2 October 2017

1 reference

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Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B.

2 October 2017

1 reference

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The consolidation of object and context recognition memory involve different regions of the temporal lobe.

11 July 2018

1 reference

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Crystal structure and mechanism of human lysine-specific demethylase-1.

23 September 2018

1 reference

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Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process

23 September 2018

1 reference

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Screening assays for epigenetic targets using native histones as substrates

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22754608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22754608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22754608

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CN200104Y

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22754608%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22754608%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22754608%20AND%20SRC:MED&resulttype=core&format=json