Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin. (Q36057264)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19318567%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

title

Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin (English)

1 reference

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24 January 2020

2

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24 January 2020

author name string

Min Huang

series ordinal

1

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24 January 2020

Yanping Zhang

series ordinal

3

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24 January 2020

Beverly S Mitchell

series ordinal

4

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24 January 2020

language of work or name

English

0 references

publication date

24 March 2009

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24 January 2020

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24 January 2020

volume

69

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24 January 2020

issue

7

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24 January 2020

page(s)

3004-3012

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Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2

24 January 2020

cites work

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2 October 2017

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2 October 2017

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Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway

2 October 2017

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Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption

2 October 2017

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2 October 2017

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Multiple controls regulate nucleostemin partitioning between nucleolus and nucleoplasm

2 October 2017

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Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

2 October 2017

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Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability

2 October 2017

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Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development

2 October 2017

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Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

2 October 2017

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2 October 2017

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Cellular stress and nucleolar function

2 October 2017

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Cloning of the nucleostemin gene and its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells

2 October 2017

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

2 October 2017

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Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

2 October 2017

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A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin

2 October 2017

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Going in GTP cycles in the nucleolus

2 October 2017

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Inhibition of HDM2 and activation of p53 by ribosomal protein L23

2 October 2017

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Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

2 October 2017

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Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

2 October 2017

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The ubiquitin ligase COP1 is a critical negative regulator of p53

2 October 2017

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

2 October 2017

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

2 October 2017

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

2 October 2017

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Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

2 October 2017

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Regulation of HDM2 activity by the ribosomal protein L11

2 October 2017

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

2 October 2017

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A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells

2 October 2017

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Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase

2 October 2017

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2 October 2017

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2 October 2017

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A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

2 October 2017

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23 September 2018

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

5 December 2018

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In vivo ubiquitination and proteasome-mediated degradation of p53(1)

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19318567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of Angiogenic Factors by HDM2 in Renal Cell Carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19318567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19318567

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-08-3413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19318567%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19318567%20AND%20SRC:MED&resulttype=core&format=json

24 January 2020

1 reference