Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β (Q36054191)

11 August 2017

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β (English)

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11 August 2017

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GOA release 2020-03-11

Hwan-Ching Tai

3

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ALBERTO SERRANO-POZO

Alberto Serrano-Pozo

5

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Tara L Spires-Jones

Tara L Spires-Jones

13

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David M. Holtzman

11

David M Holtzman

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11 August 2017

12

Bradley T Hyman

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11 August 2017

9

Matthew P Frosch

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11 August 2017

1

Robert M Koffie

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11 August 2017

2

Tadafumi Hashimoto

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11 August 2017

Katherine J Kopeikina

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Katherine J Kopeikina

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11 August 2017

6

Daniel Joyner

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11 August 2017

Kevin R Kay

4

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11 August 2017

Steven Hou

7

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11 August 2017

Virginia M Lee

10

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11 August 2017

language of work or name

English

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publication date

26 May 2012

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11 August 2017

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135

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2155-2168

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11 August 2017

Pt 7

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3381721/fullTextXML

inferred from PubMed Central ID database lookup

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Functional interactions of APP with the apoE receptor family

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

2 October 2017

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Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

2 October 2017

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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta

2 October 2017

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Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

2 October 2017

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

2 October 2017

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Apolipoprotein E alleles as risk factors in Alzheimer's disease

2 October 2017

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2 October 2017

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2 October 2017

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

2 October 2017

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

2 October 2017

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Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

2 October 2017

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Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

2 October 2017

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Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

11 July 2018

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Biochemical characterization of a filtered synaptoneurosome preparation from guinea pig cerebral cortex: cyclic adenosine 3':5'-monophosphate-generating systems, receptors, and enzymes

11 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model

11 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP.

23 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk

23 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

23 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

23 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

23 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Is Alzheimer's disease an apolipoprotein E amyloidosis?

23 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Clinical and pathological correlates of apolipoprotein E ?4 in Alzheimer's disease

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

The association between APOE ε4, age and outcome after head injury: a prospective cohort study

21 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381721

Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema

5 December 2018

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12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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12 December 2020

Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWS127

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11 August 2017

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11 August 2017

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