Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men (Q36047495)

11 August 2017

Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men (English)

1 reference

11 August 2017

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1 reference

15

Johanna Kuusisto

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Mika Ala-Korpela

16

Mika Ala-Korpela

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Francis Collins

14

Francis S Collins

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Jussi Pihlajamäki

8

Jussi Pihlajamäki

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Jussi Paananen

7

Jussi Paananen

1 reference

11 August 2017

2

Mete Civelek

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Aldons Jake Lusis

13

Aldons J Lusis

1 reference

11 August 2017

17

Markku Laakso

1 reference

11 August 2017

Antti J Kangas

5

0 references

Michael Boehnke

11

Michael Boehnke

1 reference

11 August 2017

9

Lori L Bonnycastle

1 reference

11 August 2017

12

Päivi Pajukanta

1 reference

11 August 2017

1

Alena Stancáková

1 reference

11 August 2017

10

Mario A Morken

1 reference

11 August 2017

6

Henna Cederberg

1 reference

11 August 2017

3

Niyas K Saleem

1 reference

11 August 2017

4

Pasi Soininen

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PMCID

3379649

11 August 2017

language of work or name

English

0 references

publication date

2 May 2012

1 reference

11 August 2017

1 reference

11 August 2017

61

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11 August 2017

1895-1902

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11 August 2017

7

1 reference

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

11 August 2017

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3379649

inferred from PubMed Central ID database lookup

cites work

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Dietary leucine--an environmental modifier of insulin resistance acting on multiple levels of metabolism

2 October 2017

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Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

2 October 2017

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Metabolite profiles and the risk of developing diabetes

2 October 2017

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Metabonomic, transcriptomic, and genomic variation of a population cohort

2 October 2017

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Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women

2 October 2017

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2 October 2017

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Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

2 October 2017

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Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

2 October 2017

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

2 October 2017

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Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

2 October 2017

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A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data

2 October 2017

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Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women

2 October 2017

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

2 October 2017

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Genome-wide association studies in type 2 diabetes

2 October 2017

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Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

2 October 2017

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Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

2 October 2017

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The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population

2 October 2017

1 reference

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The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

2 October 2017

1 reference

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Potential importance of leucine in treatment of obesity and the metabolic syndrome

2 October 2017

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Follow-up report on the diagnosis of diabetes mellitus

2 October 2017

1 reference

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Amino acid ingestion strongly enhances insulin secretion in patients with long-term type 2 diabetes.

2 October 2017

1 reference

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Role of glutamine in human carbohydrate metabolism in kidney and other tissues

2 October 2017

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Bidirectional modulation of insulin action by amino acids

2 October 2017

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Regulation of gut glutamine metabolism: role of hormones and cytokines

2 October 2017

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Protein content of the diabetic diet

2 October 2017

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Stimulation of insulin secretion by amino acids

2 October 2017

1 reference

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The effect of alanine on glucagon secretion

2 October 2017

1 reference

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Amino Acid Metabolism in Man

2 October 2017

1 reference

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Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.

2 October 2017

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Short-term regulation of insulin-mediated glucose utilization in four-day fasted human volunteers: role of amino acid availability.

27 July 2018

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Regulation by insulin of amino acid release and protein turnover in the perfused rat hemicorpus

27 July 2018

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Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes

27 July 2018

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High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism

23 September 2018

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Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus

23 September 2018

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Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis.

23 September 2018

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Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity

23 September 2018

1 reference

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Direct and indirect effects of amino acids on hepatic glucose metabolism in humans

23 September 2018

1 reference

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Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379649

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379649

Insulin action on muscle protein kinetics and amino acid transport during recovery after resistance exercise.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379649

Metabolic fate of leucine: a significant sterol precursor in adipose tissue and muscle.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3379649

Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity

23 September 2018

1 reference

12 December 2020

The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte

1 reference

12 December 2020

Alanine: Key Role in Gluconeogenesis

1 reference

12 December 2020

Amino Acid and Protein Metabolism in Diabetes Mellitus

1 reference

12 December 2020

Decreased uptake of glucose by human forearm during infusion of leucine, isoleucine, or threonine

1 reference

12 December 2020

The effects of euglycemic hyperinsulinemia and amino acid infusion on regional and whole body glucose disposal in man

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12 December 2020

Effects of infused amino acids on glucose production and utilization in healthy human subjects

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12 December 2020

Identifiers

DOI

10.2337/DB11-1378

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3379649