Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke (Q36036681)

11 August 2017

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Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke (English)

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11 August 2017

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David W Howells

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Malcolm Macleod

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Malcolm R Macleod

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1

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Geoffrey A. Donnan

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Geoffrey A Donnan

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Tori O'Collins

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Tori O'Collins

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11 August 2017

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Laura L Horky

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11 August 2017

1 June 2005

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Journal of Cerebral Blood Flow & Metabolism

11 August 2017

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11 August 2017

25

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11 August 2017

713-721

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11 August 2017

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Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: therapeutic time window for FK506 in transient focal ischemia

11 August 2017

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Emergency medicine animal research: does use of randomization and blinding affect the results?

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Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain

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Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion

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Meta-analysis in clinical trials

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Early and delayed neuroprotective effects of FK506 on experimental focal ischemia quantitatively assessed by diffusion-weighted MRI.

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Systematic Reviews in Health Care

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Infarct volume on apparent diffusion coefficient maps correlates with length of stay and outcome after middle cerebral artery stroke.

21 January 2018

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Nitro-aspirin (NCX4016) reduces brain damage induced by focal cerebral ischemia in the rat

21 January 2018

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Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy

21 January 2018

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Tacrolimus, a Potential Neuroprotective Agent, Ameliorates Ischemic Brain Damage and Neurologic Deficits after Focal Cerebral Ischemia in Nonhuman Primates

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Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review

21 January 2018

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The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats.

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Clinical trials for cytoprotection in stroke

21 January 2018

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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

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Serum withdrawal causes apoptosis in SHSY 5Y cells.

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Systematic review and meta-analysis of the efficacy of melatonin in experimental stroke

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Pooling of animal experimental data reveals influence of study design and publication bias

21 January 2018

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Ketamine acts as a non-competitive N-methyl-D-aspartate antagonist on frog spinal cord in vitro.

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FK 506 protects brain tissue in animal models of stroke.

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Brain vessels normally undergo cyclic activation and inactivation: evidence from tumor necrosis factor-alpha, heme oxygenase-1, and manganese superoxide dismutase immunostaining of vessels and perivascular brain cells

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The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

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Randomized clinical trial of the effect of microemulsion cyclosporin and tacrolimus on renal allograft fibrosis

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Mild hypothermia enhances the neuroprotective effects of FK506 and expands its therapeutic window following transient focal ischemia in rats

21 January 2018

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Where is the evidence that animal research benefits humans?

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Tacrolimus (FK506) ameliorates skilled motor deficits produced by middle cerebral artery occlusion in rats.

21 January 2018

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FK506 reduces infarct volume due to permanent focal cerebral ischemia by maintaining BAD turnover and inhibiting cytochrome c release

21 January 2018

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Recommendations for standards regarding preclinical neuroprotective and restorative drug development

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Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion.

21 January 2018

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Tissue plasminogen activator for acute ischemic stroke

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Correlation of perfusion- and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) ischemic stroke.

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Neuroprotective FK506 does not alter in vivo nitric oxide production during ischemia and early reperfusion in rats

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Is diffusion imaging appearance an independent predictor of outcome after ischemic stroke?

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Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia.

21 January 2018

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Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia.

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Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

21 January 2018

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[The effect of FK 506, an immunosuppressant, on cerebral infarction volume in focal cerebral ischemia in rats]

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7 January 2021

Interplay between the gamma isoform of PKC and calcineurin in regulation of vulnerability to focal cerebral ischemia

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7 January 2021

Neuroprotective actions of FK506 in experimental stroke: in vivo evidence against an antiexcitotoxic mechanism.

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7 January 2021

Protective effect of FK506 in the reperfusion model after short-term occlusion of middle cerebral artery in the rat: assessment by autoradiography using [125I]PK-11195

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Effect of intravenous recombinant tissue plasminogen activator on ischemic stroke lesion size measured by computed tomography. NINDS; The National Institute of Neurological Disorders and Stroke (NINDS) rt-PA Stroke Study Group

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Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine

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7 January 2021

Identifiers

DOI

10.1038/SJ.JCBFM.9600064

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11 August 2017

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PubMed ID

15703698