Making better transgenic models: conditional, temporal, and spatial approaches (Q36033899)

11 August 2017

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title

Making better transgenic models: conditional, temporal, and spatial approaches (English)

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11 August 2017

Sika Ristevski

1

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PubMed ID

15699570

11 August 2017

language of work or name

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1 February 2005

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11 August 2017

Molecular Biotechnology

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11 August 2017

29

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11 August 2017

2

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11 August 2017

153-163

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https://scigraph.springernature.com/pub.10.1385/mb:29:2:153

11 August 2017

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Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes

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Age-dependent silencing of globin transgenes in the mouse

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Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.

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A steroid-inducible promoter for the controlled overexpression of cloned genes in eukaryotic cells

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Expression of genomic and cDNA transgenes after co-integration in transgenic mice

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12 December 2020

Site-specific genomic integration produces therapeutic Factor IX levels in mice

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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Ecdysone-inducible gene expression in mammalian cells and transgenic mice.

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12 December 2020

Temporal control of the Cre recombinase in transgenic mice by a tetracycline responsive promoter

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12 December 2020

YAC transgenics and the study of genetics and human disease

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12 December 2020

The cytomegalovirus enhancer: a pan-active control element in transgenic mice

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12 December 2020

Targeted integration of DNA using mutant lox sites in embryonic stem cells

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12 December 2020

Bi-directional gene switching with the tetracycline repressor and a novel tetracycline antagonist

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12 December 2020

Green fluorescent protein as a marker for gene expression

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12 December 2020

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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12 December 2020

The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice

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12 December 2020

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

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12 December 2020

Introns increase transcriptional efficiency in transgenic mice

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12 December 2020

Underexpression of the 43 kDa inositol polyphosphate 5-phosphatase is associated with cellular transformation

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12 December 2020

Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice

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12 December 2020

Mammalian CAP interacts with CAP, CAP2, and actin

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12 December 2020

Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent

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12 December 2020

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

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12 December 2020

Human T-cell leukemia virus type I tax masks c-Myc function through a cAMP-dependent pathway

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12 December 2020

Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors

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12 December 2020

Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization

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12 December 2020

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice

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12 December 2020

RNA-peptide fusions for the in vitro selection of peptides and proteins

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12 December 2020

Mammary tumor virus DNA contains sequences required for its hormone-regulated transcription

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12 December 2020

Inducible site-directed recombination in mouse embryonic stem cells

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12 December 2020

Cellular Oncogenes and Multistep Carcinogenesis

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12 December 2020

A nuclear DNA attachment element mediates elevated and position-independent gene activity

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12 December 2020

Transgenic model applications to drug discovery

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12 December 2020

Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney

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12 December 2020

Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1.

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12 December 2020

Green fluorescent protein as a reporter of gene expression in transgenic mice.

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12 December 2020

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice.

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12 December 2020

Green fluorescent fusion proteins: powerful tools for monitoring protein expression in live zebrafish embryos

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12 December 2020

Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions

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12 December 2020

Steroid receptors and their associated proteins

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12 December 2020

Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis

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12 December 2020

Characterization of replication-competent hepatitis A virus constructs containing insertions at the N terminus of the polyprotein

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12 December 2020

Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues

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12 December 2020

A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins

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12 December 2020

Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation.

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12 December 2020

The 5'-leader sequence of tobacco mosaic virus RNA enhances the expression of foreign gene transcripts in vitro and in vivo

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12 December 2020

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

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12 December 2020

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

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12 December 2020

The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors

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12 December 2020

Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

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12 December 2020

A minimal murine Msx-1 gene promoter. Organization of its cis-regulatory motifs and their role in transcriptional activation in cells in culture and in transgenic mice

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12 December 2020

A phage integrase directs efficient site-specific integration in human cells

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12 December 2020

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

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12 December 2020

Locus control region function and heterochromatin-induced position effect variegation

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12 December 2020

Transcriptional activation by tetracyclines in mammalian cells

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12 December 2020

Cell-specific expression of alpha 1(I) collagen-hGH minigenes in transgenic mice

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12 December 2020

pEF-BOS, a powerful mammalian expression vector

1 reference

12 December 2020

Heterologous introns can enhance expression of transgenes in mice

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12 December 2020

Functional relationships between transcriptional control signals of the thymidine kinase gene of herpes simplex virus

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12 December 2020

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA

1 reference

12 December 2020

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice

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12 December 2020

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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12 December 2020

Repeat-induced gene silencing in mammals.

1 reference

12 December 2020

Identification of residues in the estrogen receptor that confer differential sensitivity to estrogen and hydroxytamoxifen

1 reference

12 December 2020

Regulation of protein activities by fusion to steroid binding domains

1 reference

12 December 2020

Steroid-binding domains for regulating the functions of heterologous proteins in cis

1 reference

12 December 2020

The responsiveness of embryonic stem cells to alpha and beta interferons provides the basis of an inducible expression system for analysis of developmental control genes

1 reference

12 December 2020

Germ-line transformation of mice

1 reference

12 December 2020

A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.

1 reference

12 December 2020

Ribonucleotide reductase R2 component is a novel malignancy determinant that cooperates with activated oncogenes to determine transformation and malignant potential

1 reference

12 December 2020

The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice

1 reference

12 December 2020

Interferons and their actions

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12 December 2020

In vivo sequence requirements of the SV40 early promoter region

1 reference

12 December 2020

The jellyfish green fluorescent protein: a new tool for studying ion channel expression and function

1 reference

12 December 2020

Scaffold-attached regions from the human interferon beta domain can be used to enhance the stable expression of genes under the control of various promoters

1 reference

12 December 2020

Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.

1 reference

12 December 2020

NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice

1 reference

12 December 2020

Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts

1 reference

12 December 2020

Self-contained, tetracycline-regulated retroviral vector system for gene delivery to mammalian cells

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12 December 2020

The mouse metallothionein-I gene is transcriptionally regulated by cadmium following transfection into human or mouse cells

1 reference

12 December 2020

Functional analysis of the steroid hormone control region of mouse mammary tumor virus

1 reference

12 December 2020

Production of transgenic mice with yeast artificial chromosomes

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12 December 2020

A generic intron increases gene expression in transgenic mice

1 reference

12 December 2020

Activation of multiple growth regulatory genes following inducible expression of IRF-1 or IRF/RelA fusion proteins

1 reference

12 December 2020

In vitro motility from recombinant dynein heavy chain

1 reference

12 December 2020

Inducible gene targeting in mice

1 reference

12 December 2020

Developmental analysis of the cytomegalovirus enhancer in transgenic animals

1 reference

12 December 2020

Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells

1 reference

12 December 2020

Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2.

1 reference

12 December 2020

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

12 December 2020

Identification of an autonomously initiating RNA polymerase III holoenzyme containing a novel factor that is selectively inactivated during protein synthesis inhibition

1 reference

12 December 2020

Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice

1 reference

12 December 2020

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

1 reference

12 December 2020

Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.

1 reference

12 December 2020

Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells

1 reference

12 December 2020

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

1 reference

12 December 2020

Variegated gene expression in mice.

1 reference

12 December 2020

Mammary gland morphogenesis is inhibited in transgenic mice that overexpress cell surface beta1,4-galactosyltransferase

1 reference

12 December 2020

Control of memory formation through regulated expression of a CaMKII transgene

1 reference

12 December 2020

Genome engineering using site-specific recombinases

1 reference

12 December 2020

Identifiers

DOI

10.1385/MB:29:2:153

1 reference

PubMed ID

15699570

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15699570