Caveolin-1 in oncogenic transformation, cancer, and metastasis (Q36030347)

11 August 2017

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title

Caveolin-1 in oncogenic transformation, cancer, and metastasis (English)

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11 August 2017

2

Michael P Lisanti

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11 August 2017

Terence M Williams

1

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11 August 2017

1 March 2005

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American Journal of Physiology - Cell Physiology

11 August 2017

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11 August 2017

288

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11 August 2017

C494-506

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11 August 2017

3

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Downmodulation of caveolin-1 expression in human ovarian carcinoma is directly related to alpha-folate receptor overexpression

11 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Role of caveolin-1 in etoposide resistance development in A549 lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Role of transforming growth factor beta in breast carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Differential gene expression in metastasizing cells shed from kidney tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 overexpression predicts poor disease-free survival of patients with clinically confined renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin expression in adult renal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

The expression of rho proteins decreases with human brain tumor progression: potential tumor markers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 expression negatively regulates cell cycle progression by inducing G(0)/G(1) arrest via a p53/p21(WAF1/Cip1)-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Expression of caveolin-1 in human T cell leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Up-regulated caveolin-1 accentuates the metastasis capability of lung adenocarcinoma by inducing filopodia formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Impact of caveolin-1 expression on clinicopathological parameters in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

The cyclin D1 gene is transcriptionally repressed by caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

The biphasic differential expression of the cellular membrane protein, caveolin-1, in oral carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 overexpression is an early event in the progression of papillary carcinoma of the thyroid

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Reduction of caveolin and caveolae in oncogenically transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Tumorigenic conversion of endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Palmitoylation of caveolin-1 at a single site (Cys-156) controls its coupling to the c-Src tyrosine kinase: targeting of dually acylated molecules (GPI-linked, transmembrane, or cytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TY

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Evidence for a regulated interaction between heterotrimeric G proteins and caveolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Multiple functions of caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Genetic alterations in hormone-refractory recurrent prostate carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Evidence that Myc isoforms transcriptionally repress caveolin-1 gene expression via an INR-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane. Retention of caveolin-2 at the level of the golgi complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin expression is decreased following androgen deprivation in human prostate cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Reduction of caveolin 1 gene expression in lung carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 expression is down-regulated in cells transformed by the human papilloma virus in a p53-dependent manner. Replacement of caveolin-1 expression suppresses HPV-mediated cell transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolae: from cell biology to animal physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

The two faces of transforming growth factor beta in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin, a protein component of caveolae membrane coats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Clinical significance of Caveolin-1, Caveolin-2 and HER2/neu mRNA expression in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 expression is a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Involvement of caveolin-1 in meiotic cell-cycle progression in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Cell-type and tissue-specific expression of caveolin-2. Caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 inhibits breast cancer growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

A detergent-free method for purifying caveolae membrane from tissue culture cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 is regulated by c-myc and suppresses c-myc-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

M-caveolin, a muscle-specific caveolin-related protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolins as tumour markers in lung cancer detected by combined use of cDNA and tissue microarrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPCELL.00458.2004

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1074/JBC.M105408200

Identifiers

DOI

10.1152/AJPCELL.00458.2004

1 reference

11 August 2017

1 reference

PubMed ID

15692148