Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase. (Q36027390)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22689655%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase (English)

1 reference

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4 February 2020

5

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4 February 2020

author name string

Eric M Rubenstein

1

1 reference

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4 February 2020

Stefan G Kreft

2

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4 February 2020

Wesley Greenblatt

3

1 reference

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4 February 2020

Robert Swanson

4

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4 February 2020

language of work or name

English

0 references

publication date

1 June 2012

1 reference

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4 February 2020

published in

Journal of Cell Biology

1 reference

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4 February 2020

volume

197

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4 February 2020

page(s)

761-773

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4 February 2020

issue

6

1 reference

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describes a project that uses

4 February 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3373407/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Membrane protein insertion at the endoplasmic reticulum

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Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity

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Functional and genomic analyses of blocked protein O-mannosylation in baker's yeast

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Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p

2 October 2017

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Protein translocation across the ER membrane

2 October 2017

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Modularity of the Hrd1 ERAD complex underlies its diverse client range

2 October 2017

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Usa1 functions as a scaffold of the HRD-ubiquitin ligase.

2 October 2017

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Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase

2 October 2017

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Sec61p is part of the endoplasmic reticulum-associated degradation machinery

2 October 2017

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Protein O-mannosylation: conserved from bacteria to humans

2 October 2017

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Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase

2 October 2017

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Mechanisms targeting apolipoprotein B100 to proteasomal degradation: evidence that degradation is initiated by BiP binding at the N terminus and the formation of a p97 complex at the C terminus

2 October 2017

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Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.

2 October 2017

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Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

2 October 2017

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Diversity of degradation signals in the ubiquitin-proteasome system

2 October 2017

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Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins

2 October 2017

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The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway

2 October 2017

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The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

2 October 2017

1 reference

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O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.

2 October 2017

1 reference

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The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD)

2 October 2017

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Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis

2 October 2017

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

2 October 2017

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The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

2 October 2017

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Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

2 October 2017

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The Png1-Rad23 complex regulates glycoprotein turnover

2 October 2017

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Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)

2 October 2017

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Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.

2 October 2017

1 reference

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Yos9p detects and targets misfolded glycoproteins for ER-associated degradation

2 October 2017

1 reference

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Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen

2 October 2017

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A genome-wide screen identifies Yos9p as essential for ER-associated degradation of glycoproteins

2 October 2017

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An efficient one-step site-directed and site-saturation mutagenesis protocol

2 October 2017

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Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein

2 October 2017

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Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control

2 October 2017

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2 October 2017

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Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state

2 October 2017

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Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 protein.

2 October 2017

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Overexpression of the tumor autocrine motility factor receptor Gp78, a ubiquitin protein ligase, results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in HepG2 cells

2 October 2017

1 reference

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Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding

2 October 2017

1 reference

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A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Sec62p, a component of the endoplasmic reticulum protein translocation machinery, contains multiple binding sites for the Sec-complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Rapid and reliable protein extraction from yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

HRD gene dependence of endoplasmic reticulum-associated degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Cer1p functions as a molecular chaperone in the endoplasmic reticulum of Saccharomyces cerevisiae

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Role of Cue1p in ubiquitination and degradation at the ER surface

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Signal sequences specify the targeting route to the endoplasmic reticulum membrane

2 October 2017

1 reference

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ER membrane protein complex required for nuclear fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

A nascent secretory protein may traverse the ribosome/endoplasmic reticulum translocase complex as an extended chain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Rhodanine-3-acetic acid derivatives as inhibitors of fungal protein mannosyl transferase 1 (PMT1).

11 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.201203061

Co-translational interactions of apoprotein B with the ribosome and translocon during lipoprotein assembly or targeting to the proteasome

21 January 2018

1 reference

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https://api.crossref.org/works/10.1083%2FJCB.201203061

The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3373407

Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22689655

12 December 2020

inferred from PubMed ID database lookup

Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22689655

12 December 2020

inferred from PubMed ID database lookup

Mapping the ends of transmembrane segments in a polytopic membrane protein. Scanning N-glycosylation mutagenesis of extracytosolic loops in the anion exchanger, band 3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22689655

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1083/JCB.201203061

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22689655%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22689655%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22689655%20AND%20SRC:MED&resulttype=core&format=json