The aggravating role of the ubiquitin-proteasome system in neurodegeneration (Q36020204)

11 August 2017

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title

The aggravating role of the ubiquitin-proteasome system in neurodegeneration (English)

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ubiquitin-proteasome system

11 August 2017

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author name string

Helen C Ardley

series ordinal

1

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11 August 2017

Chao-Chun Hung

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2

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11 August 2017

Philip A Robinson

series ordinal

3

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11 August 2017

language of work or name

English

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publication date

1 January 2005

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11 August 2017

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11 August 2017

579

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11 August 2017

3

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11 August 2017

571-576

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Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie

11 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Back to the future with ubiquitin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

How the ubiquitin-proteasome system controls transcription

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Antigen processing by the proteasome

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Protein regulation by monoubiquitin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

SUMO, ubiquitin's mysterious cousin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

A superfamily of protein tags: ubiquitin, SUMO and related modifiers

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Dementia, gliosis and expression of the small heat shock proteins hsp27 and alpha B-crystallin in Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

alpha B crystallin expression in non-lenticular tissues and selective presence in ubiquitinated inclusion bodies in human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Immunohistochemical localization of neurofilament protein in neuronal degenerations.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Aggresomes: a cellular response to misfolded proteins

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Parkin accumulation in aggresomes due to proteasome impairment

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Hassles with taking out the garbage: aggravating aggresomes.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

The role of ubiquitin-protein ligases in neurodegenerative disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Parkin facilitates the elimination of expanded polyglutamine proteins and leads to preservation of proteasome function.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Dorfin Localizes to Lewy Bodies and Ubiquitylates Synphilin-1

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Association of ataxin-7 with the proteasome subunit S4 of the 19S regulatory complex

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

The ubiquitin pathway in Parkinson's disease.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Co-association of parkin and alpha-synuclein

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Siah-1 facilitates ubiquitination and degradation of synphilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Characterization of chronic low-level proteasome inhibition on neural homeostasis.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

SUMO-1 co-localized with mutant atrophin-1 with expanded polyglutamines accelerates intranuclear aggregation and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Aging and molecular chaperones

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Oxidative stress and genetics in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2004.12.058

10.1016/J.FEBSLET.2004.12.058

21 January 2018

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DOI

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11 August 2017

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