Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells (Q36001852)

11 August 2017

Targeting the epigenome: effects of epigenetic treatment strategies on genomic stability in healthy human cells (English)

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11 August 2017

2

Ulrich Mahlknecht

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11 August 2017

Jan C Purrucker

1

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11 August 2017

27 July 2010

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11 August 2017

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11 August 2017

1

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11 August 2017

1-2

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11 August 2017

45-54

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https://scigraph.springernature.com/pub.10.1007/s13148-010-0007-1

11 August 2017

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cites work

Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group

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Targeting DNA methylation

2 October 2017

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Valproic acid in pregnancy: how much are we endangering the embryo and fetus?

2 October 2017

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Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

2 October 2017

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Valproic acid and all-trans retinoic acid: meta-analysis of a palliative treatment regimen in AML and MDS patients

2 October 2017

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Chromatin remodeling finds its place in the DNA double-strand break response

2 October 2017

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Histone deacetylase inhibitors blocked activation and caused senescence of corneal stromal cells

2 October 2017

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HDAC family: What are the cancer relevant targets?

2 October 2017

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Postradiation sensitization of the histone deacetylase inhibitor valproic acid

2 October 2017

1 reference

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Histone deacetylase inhibitors and genomic instability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments

2 October 2017

1 reference

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Defining 'chromosomal instability'.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Computed Tomography — An Increasing Source of Radiation Exposure

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

New nomenclature for chromatin-modifying enzymes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Radiosensitization by the histone deacetylase inhibitor PCI-24781.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

The mechanism of human nonhomologous DNA end joining

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Inhibition of histone deacetylation: a strategy for tumor radiosensitization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Sirtuins: the 'magnificent seven', function, metabolism and longevity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Differential effects of histone deacetylase inhibitors in tumor and normal cells-what is the toxicological relevance?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Carbamazepine is an inhibitor of histone deacetylases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Cancer risk in people with epilepsy: the role of antiepileptic drugs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Role of histone deacetylase inhibitors in the treatment of cancer (Review).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone deacetylase inhibitors: understanding a new wave of anticancer agents

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone acetylation modifiers in the pathogenesis of malignant disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

An analysis of the "carry-over effect" following successful short-term treatment of transformed migraine with divalproex sodium

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

The pharmacologic basis of antiepileptic drug action

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Frequencies of occurrence of all human chromosomes in micronuclei from normal and 5-azacytidine-treated lymphocytes as revealed by chromosome painting

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Segmentation of human chromosomes induced by 5-ACR (5-azacytidine)

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Suppression of adiponectin gene expression by histone deacetylase inhibitor valproic acid

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Valproic acid: reversibly acting drug?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid

11 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

The activity of antiepileptic drugs as histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

Cancer risk in long-term users of valproate: a population-based case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

Mechanisms of DNA breaks induction in vivo by 5-azacytidine: paths of micronucleus induction by azaC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

Valproic acid blood genomic expression patterns in children with epilepsy - a pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3365366

Histone deacetylase inhibitors in cancer therapy

23 September 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13148-010-0007-1

5-Azacytidine-induced undercondensations in human chromosomes

21 January 2018

1 reference

12 December 2020

Exclusion of specific human chromosomes into micronuclei by 5-azacytidine treatment of lymphocyte cultures

1 reference

12 December 2020

Effects of 5-azacytidine on the centromeric region of human fibroblasts studied by CREST staining and in situ hybridization on cytokinesis-blocked cells

1 reference

12 December 2020

Histone deacetylase inhibitors as potential anti-skin cancer agents

1 reference

12 December 2020

Inhibition of repair of X-ray-induced DNA double-strand breaks in human lymphocytes exposed to sodium butyrate

1 reference

12 December 2020

Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts

1 reference

12 December 2020

CpG island methylator phenotype in cancer

1 reference

12 December 2020

5-Azacytidine, a new, highly effective cancerostatic

1 reference

12 December 2020

10.1007/S13148-010-0007-1

Identifiers

DOI

1 reference

PMCID

3365366

Dimensions Publication ID

11 August 2017

0 references

1 reference

11 August 2017

1 reference

PMCID

3365366