Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication. (Q35989395)

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22 February 2020

title

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication (English)

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22 February 2020

6

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22 February 2020

author name string

FuJung Chang

1

1 reference

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22 February 2020

Alberto Riera

2

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22 February 2020

Cecile Evrin

3

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22 February 2020

Jingchuan Sun

4

1 reference

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22 February 2020

Huilin Li

5

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22 February 2020

Michael Weinreich

7

1 reference

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22 February 2020

language of work or name

English

0 references

publication date

25 August 2015

1 reference

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22 February 2020

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22 February 2020

volume

4

1 reference

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A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA

22 February 2020

cites work

1 reference

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Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

2 October 2017

1 reference

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The bacterial DnaC helicase loader is a DnaB ring breaker

2 October 2017

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Loading and activation of DNA replicative helicases: the key step of initiation of DNA replication

2 October 2017

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Genomic instability in cancer

2 October 2017

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A structural framework for replication origin opening by AAA+ initiation factors.

2 October 2017

1 reference

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MCM structure and mechanics: what we have learned from archaeal MCM.

2 October 2017

1 reference

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Structure and function of the AAA+ nucleotide binding pocket

2 October 2017

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The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

2 October 2017

1 reference

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How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

2 October 2017

1 reference

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The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.

2 October 2017

1 reference

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Conserved nucleosome positioning defines replication origins

2 October 2017

1 reference

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A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Insights into the architecture of the replicative helicase from the structure of an archaeal MCM homolog

2 October 2017

1 reference

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Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication

2 October 2017

1 reference

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EMAN2: an extensible image processing suite for electron microscopy

2 October 2017

1 reference

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Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

AAA+ proteins: have engine, will work

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Eukaryotic MCM proteins: beyond replication initiation

2 October 2017

1 reference

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The DnaC helicase loader is a dual ATP/ADP switch protein

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

2 October 2017

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Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex

2 October 2017

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A human protein related to yeast Cdc6p

2 October 2017

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An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast

2 October 2017

1 reference

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Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Multiple functions for Mcm2-7 ATPase motifs during replication initiation

2 October 2017

1 reference

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Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase

11 July 2018

1 reference

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An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Improved flow cytometric analysis of the budding yeast cell cycle.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Nucleotide-dependent prereplicative complex assembly by Cdc6p, a homolog of eukaryotic and prokaryotic clamp-loaders.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

Butyrolactone: more than a kinase inhibitor?

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.7554%2FELIFE.05795

Prereplication-complex formation: a molecular double take?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4547096

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

14 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26305410

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.05795

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26305410%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26305410%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference