Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors (Q35974738)

11 August 2017

Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors (English)

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11 August 2017

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Sergiy I Borysov

1

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11 August 2017

Antoneta Granic

2

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11 August 2017

Jaya Padmanabhan

3

1 reference

11 August 2017

Claire E Walczak

4

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11 August 2017

Huntington Potter

5

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11 August 2017

1 May 2011

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11 August 2017

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11 August 2017

10

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11 August 2017

9

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11 August 2017

1397-1410

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Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Selective cell death of hyperploid neurons in Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Structural classification of toxic amyloid oligomers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

The mitotic kinesin CENP-E is a processive transport motor.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Mechanisms of mitotic spindle assembly and function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

A hundred years of Alzheimer's disease research

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Human chromokinesin KIF4A functions in chromosome condensation and segregation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Microtubular interactions of presenilin direct kinesis of Aβ peptide and its precursors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

The secretases of Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Tau is essential to beta -amyloid-induced neurotoxicity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Molecular motors: from one motor many tails to one motor many tales

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

What the evolution of the amyloid protein precursor supergene family tells us about its function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Microtubule-based motor function in mitosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

KIF2 is a new microtubule-based anterograde motor that transports membranous organelles distinct from those carried by kinesin heavy chain or KIF3A/B.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

The consequences of chromosome imbalance

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Stepping and stretching. How kinesin uses internal strain to walk processively

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Expression of the mitotic motor protein Eg5 in postmitotic neurons: implications for neuronal development.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Spontaneous and induced aneuploidy in peripheral blood lymphocytes of patients with Alzheimer's disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

11 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Chromosome studies of patients with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Association between presenilin-1 -48C/T polymorphism and Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Association between presenilin-1 polymorphism and maternal meiosis II errors in Down syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Transient exposure to the Eg5 kinesin inhibitor monastrol leads to syntelic orientation of chromosomes and aneuploidy in mouse oocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Analysis of microtubule polymerization in vitro and during the cell cycle in Xenopus egg extracts.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Xklp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

Development of high-throughput screens for discovery of kinesin adenosine triphosphatase modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.10.9.15478

mRNA expression of KIF1A, KIF1B, KIF2, KIF3A, KIF3B, KIF4, KIF5, and cytoplasmic dynein during axonal regeneration.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Age-specific incidence of Alzheimer's disease in a community population.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356829

Aneuploidy induction by mitotic arrestants in animal cell systems: possible mechanisms

24 September 2018

1 reference

12 December 2020

Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age

1 reference

12 December 2020

Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients

1 reference

12 December 2020

A new function of microtubule-associated protein tau: involvement in chromosome stability

1 reference

12 December 2020

Cell cycle aberrations in Alzheimer's disease: a novel therapeutic opportunity

1 reference

12 December 2020

Identifiers

DOI

10.4161/CC.10.9.15478

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

21566458

1 reference