Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38. (Q35956476)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7991583%20AND%20SRC:MED&resulttype=core&format=json

30 October 2019

title

Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38 (English)

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30 October 2019

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1

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30 October 2019

author name string

E A Padlan

2

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30 October 2019

S H Jung

3

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30 October 2019

B Lee

4

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30 October 2019

I Pastan

5

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30 October 2019

language of work or name

English

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publication date

1 December 1994

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30 October 2019

number of pages

5

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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30 October 2019

volume

91

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30 October 2019

issue

25

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30 October 2019

page(s)

12051-12055

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Preclinical evaluation of 111In-labeled B3 monoclonal antibody: biodistribution and imaging studies in nude mice bearing human epidermoid carcinoma xenografts

30 October 2019

cites work

1 reference

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A recombinant immunotoxin containing a disulfide-stabilized Fv fragment

2 October 2017

1 reference

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Humanization of murine monoclonal antibodies through variable domain resurfacing

2 October 2017

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Cloning and sequencing of human immunoglobulin V lambda gene segments

2 October 2017

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A comprehensive set of sequence analysis programs for the VAX

2 October 2017

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Contribution of human VκII germ-line genes to light-chain diversity

2 October 2017

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Structure and activity of diphtheria toxin. I. Thiol-dependent dissociation of a fraction of toxin into enzymically active and inactive fragments

2 October 2017

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Rapid and efficient site-specific mutagenesis without phenotypic selection

2 October 2017

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Replacing the complementarity-determining regions in a human antibody with those from a mouse

2 October 2017

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Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

2 October 2017

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Reshaping human antibodies for therapy

2 October 2017

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Phosphocholine binding immunoglobulin Fab McPC603. An X-ray diffraction study at 2.7 A

2 October 2017

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A humanized antibody that binds to the interleukin 2 receptor

2 October 2017

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Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45374

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45374

Preparation of genetically engineered monoclonal antibodies for human immunotherapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=45374

Comparison of surface accessible residues in human and murine immunoglobulin Fv domains. Implication for humanization of murine antibodies.

2 October 2017

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Early restriction of the human antibody repertoire.

11 July 2018

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Potential of primate monoclonal antibodies to substitute for human antibodies: nucleotide sequence of chimpanzee Fab fragments.

11 July 2018

1 reference

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Evolutionary relationship between human and mouse immunoglobulin kappa light chain variable region genes

11 July 2018

1 reference

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Structural repertoire of the human VH segments

11 July 2018

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Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

11 July 2018

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Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.

24 September 2018

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Reshaping human antibodies: grafting an antilysozyme activity.

24 September 2018

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A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties

24 September 2018

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12 December 2020

Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas

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12 December 2020

A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies

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12 December 2020

"Primatization" of recombinant antibodies for immunotherapy of human diseases: a macaque/human chimeric antibody against human CD4

1 reference

12 December 2020

Idiotope determining regions of a mouse monoclonal antibody and its humanized versions

1 reference

12 December 2020

Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.91.25.12051

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7991583%20AND%20SRC:MED&resulttype=core&format=json

30 October 2019

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:7991583%20AND%20SRC:MED&resulttype=core&format=json

30 October 2019

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