Inflammatory networks underlying colorectal cancer (Q35925068)

11 August 2017

Inflammatory networks underlying colorectal cancer (English)

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11 August 2017

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Audrey Lasry

1

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11 August 2017

Adar Zinger

series ordinal

2

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11 August 2017

Yinon Ben-Neriah

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3

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11 August 2017

language of work or name

English

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publication date

1 February 2016

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11 August 2017

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11 August 2017

17

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11 August 2017

3

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11 August 2017

230-240

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Aspirin and COX-2 inhibitor use in patients with stage III colon cancer

11 August 2017

1 reference

12 December 2020

IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT001065

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12 December 2020

The origins of tumor-promoting inflammation.

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12 December 2020

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

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12 December 2020

Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth.

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12 December 2020

Development of anti-TNF therapy for rheumatoid arthritis

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12 December 2020

Paneth cells as a site of origin for intestinal inflammation.

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12 December 2020

Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis.

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12 December 2020

Interferons, immunity and cancer immunoediting

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12 December 2020

Emerging cytokine networks in colorectal cancer.

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12 December 2020

Genetics and pathogenesis of inflammatory bowel disease

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12 December 2020

FDA approval: siltuximab for the treatment of patients with multicentric Castleman disease

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12 December 2020

Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.

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12 December 2020

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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12 December 2020

The gut flora as a forgotten organ

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12 December 2020

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

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12 December 2020

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

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12 December 2020

Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin

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12 December 2020

Enhanced expression of cyclooxygenase-2 in high grade human transitional cell bladder carcinomas

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12 December 2020

The influence of anti-TNF therapy upon incidence of keratinocyte skin cancer in patients with rheumatoid arthritis: longitudinal results from the British Society for Rheumatology Biologics Register

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12 December 2020

Five-year efficacy and safety analysis of the Adenoma Prevention with Celecoxib Trial

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12 December 2020

Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A

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12 December 2020

Inflammasomes in health and disease

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12 December 2020

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

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12 December 2020

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

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12 December 2020

A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism

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12 December 2020

Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

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12 December 2020

COX-2 and NF-KB overexpression is common in pancreatic cancer but does not predict for COX-2 inhibitors activity in combination with gemcitabine and oxaliplatin.

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12 December 2020

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

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12 December 2020

Role of autophagy in the maintenance and function of cancer stem cells

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12 December 2020

Anti-TNF therapy in inflammatory bowel diseases: a huge review.

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12 December 2020

Deficient DNA mismatch repair: a common etiologic factor for colon cancer

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12 December 2020

Role of autophagy in cancer

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12 December 2020

Impacts of gut bacteria on human health and diseases.

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12 December 2020

Why not treat human cancer with interleukin-1 blockade?

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12 December 2020

Sulindac suppresses tumorigenesis in the Min mouse.

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12 December 2020

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

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12 December 2020

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

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12 December 2020

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases

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12 December 2020

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

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12 December 2020

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

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12 December 2020

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

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12 December 2020

A phase I/II, multiple-dose, dose-escalation study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with advanced solid tumors

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12 December 2020

Pattern recognition receptors and inflammation

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12 December 2020

Sulindac for polyposis of the colon.

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12 December 2020

Inflammation meets cancer, with NF-κB as the matchmaker

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12 December 2020

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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12 December 2020

Identification and characterization of the familial adenomatous polyposis coli gene

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12 December 2020

Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.

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12 December 2020

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

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12 December 2020

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

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12 December 2020

Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma

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12 December 2020

Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer

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12 December 2020

Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium's epithelial niche

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12 December 2020

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

1 reference

12 December 2020

A cytokine-mediated link between innate immunity, inflammation, and cancer

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12 December 2020

Mechanisms of inflammasome activation: recent advances and novel insights

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12 December 2020

Innate immune mechanisms of colitis and colitis-associated colorectal cancer

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12 December 2020

Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon

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12 December 2020

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

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12 December 2020

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

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12 December 2020

A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer

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12 December 2020

Microbes, microbiota, and colon cancer

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12 December 2020

Hallmarks of Cancer: The Next Generation

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12 December 2020

Enterotoxigenic Bacteroides fragilis (ETBF)-mediated colitis in Min (Apc+/-) mice: a human commensal-based murine model of colon carcinogenesis

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12 December 2020

Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling

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12 December 2020

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12 December 2020

Long-term use of aspirin and the risk of gastrointestinal bleeding

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12 December 2020

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

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12 December 2020

NF-κB inhibition delays DNA damage-induced senescence and aging in mice

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12 December 2020

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

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12 December 2020

Autophagy in cellular metabolism and cancer

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12 December 2020

TLR9 and the NLRP3 inflammasome link acinar cell death with inflammation in acute pancreatitis

1 reference

12 December 2020

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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12 December 2020

Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications

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12 December 2020

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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12 December 2020

Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.

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12 December 2020

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

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12 December 2020

Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury

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12 December 2020

An international association between Helicobacter pylori infection and gastric cancer. The EUROGAST Study Group

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12 December 2020

The role of COX-2 in intestinal cancer

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12 December 2020

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

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12 December 2020

Prostaglandin E2 increases growth and motility of colorectal carcinoma cells

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12 December 2020

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

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12 December 2020

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

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12 December 2020

The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.

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12 December 2020

COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirin

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12 December 2020

Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients

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12 December 2020

Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes

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12 December 2020

Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe

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12 December 2020

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

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12 December 2020

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

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12 December 2020

Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation

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12 December 2020

Sulindac causes regression of rectal polyps in familial adenomatous polyposis

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12 December 2020

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

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12 December 2020

Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.

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12 December 2020

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

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12 December 2020

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

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12 December 2020

Critical role for IL-1β in DNA damage-induced mucositis.

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12 December 2020

p53 mutations in colorectal cancer

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12 December 2020

Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease.

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12 December 2020

The intestinal epithelium as guardian of gut barrier integrity

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12 December 2020

Ectopic lymphoid-like structures in infection, cancer and autoimmunity

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12 December 2020

Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

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12 December 2020

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

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12 December 2020

The role of cyclooxygenases in inflammation, cancer, and development

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12 December 2020

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

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12 December 2020

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

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12 December 2020

Inflammasomes of the intestinal epithelium

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12 December 2020

Incidence of serious respiratory infections in patients with rheumatoid arthritis treated with tocilizumab.

1 reference

12 December 2020

APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits"

1 reference

12 December 2020

Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial

1 reference

12 December 2020

Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori

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12 December 2020

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

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12 December 2020

Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack

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12 December 2020

Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome

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12 December 2020

The inflammasome: a danger sensing complex triggering innate immunity

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12 December 2020

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

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12 December 2020

Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation

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12 December 2020

The multifaceted Paneth cell

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12 December 2020

Aspirin use and survival after the diagnosis of breast cancer: a population-based cohort study

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12 December 2020

A diverse range of gene products are effectors of the type I interferon antiviral response

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12 December 2020

Endemic fungal infections in inflammatory bowel disease associated with anti-TNF antibody therapy

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12 December 2020

Epithelial metaplasia: adult stem cell reprogramming and (pre)neoplastic transformation mediated by inflammation?

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12 December 2020

A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis

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12 December 2020

Colorectal cancer in mice genetically deficient in the mucin Muc2

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12 December 2020

Case-control study of aspirin use and risk of pancreatic cancer

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12 December 2020

Epithelial-derived IL-18 regulates Th17 cell differentiation and Foxp3⁺ Treg cell function in the intestine.

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12 December 2020

Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe.

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12 December 2020

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

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12 December 2020

Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs

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12 December 2020

Trends in overall and cause-specific mortality among patients with inflammatory bowel disease from 1982 to 2010.

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12 December 2020

Intestinal mucosal barrier function in health and disease

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12 December 2020

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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12 December 2020

Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival

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12 December 2020

Prostaglandin E2 modulates components of the Wnt signaling system in bone and prostate cancer cells

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12 December 2020

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

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12 December 2020

Tertiary lymphoid structures in cancer and beyond

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12 December 2020

Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy

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12 December 2020

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

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12 December 2020

Anti-TNF immunotherapy reduces CD8+ T cell-mediated antimicrobial activity against Mycobacterium tuberculosis in humans

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12 December 2020

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

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12 December 2020

Importance of disrupted intestinal barrier in inflammatory bowel diseases

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12 December 2020

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

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12 December 2020

Helicobacter pylori infection and the risk of gastric carcinoma

1 reference

12 December 2020

CKIα ablation highlights a critical role for p53 in invasiveness control

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12 December 2020

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

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12 December 2020

Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma

1 reference

12 December 2020

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

1 reference

12 December 2020

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

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12 December 2020

The nature of the principal type 1 interferon-producing cells in human blood

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12 December 2020

Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas

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12 December 2020

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

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12 December 2020

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12 December 2020

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.

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12 December 2020

DNA excision repair: where do all the dimers go?

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12 December 2020

Aspirin use and reduced risk of fatal colon cancer

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12 December 2020

AIMing 2 Curtail Cancer.

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12 December 2020

Clinical use of anti-TNF therapy and increased risk of infections

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12 December 2020

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

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12 December 2020

Expression of COX-2 in stomach cancers and its relation to their biological features.

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12 December 2020

Molecular detection, quantification, and isolation of Streptococcus gallolyticus bacteria colonizing colorectal tumors: inflammation-driven potential of carcinogenesis via IL-1, COX-2, and IL-8.

1 reference

12 December 2020

An international association between Helicobacter pylori infection and gastric cancer

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNI.3384

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NI.3384

1 reference

11 August 2017

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