The 8q24 gene desert: an oasis of non-coding transcriptional activity. (Q35919877)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558003%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

title

The 8q24 gene desert: an oasis of non-coding transcriptional activity (English)

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31 January 2020

4

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31 January 2020

author name string

Konrad Huppi

series ordinal

1

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31 January 2020

Jason J Pitt

series ordinal

2

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31 January 2020

Brady M Wahlberg

series ordinal

3

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31 January 2020

publication date

30 April 2012

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31 January 2020

published in

Frontiers in Genetics

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31 January 2020

volume

3

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31 January 2020

page(s)

69

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Non-coding RNAs in human disease

31 January 2020

cites work

1 reference

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RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders

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A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression

27 July 2018

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Functional characterization of the plasmacytoma variant translocation 1 gene (PVT1) in diabetic nephropathy

27 July 2018

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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

27 July 2018

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Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility

27 July 2018

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A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24.

27 July 2018

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An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer

27 July 2018

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Genome-wide association study identifies five new breast cancer susceptibility loci

27 July 2018

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The landscape of somatic copy-number alteration across human cancers

27 July 2018

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Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer

27 July 2018

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Long-range enhancers on 8q24 regulate c-Myc

27 July 2018

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Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells

27 July 2018

1 reference

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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

27 July 2018

1 reference

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Evaluation of the 8q24 prostate cancer risk locus and MYC expression.

27 July 2018

1 reference

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High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors

27 July 2018

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

27 July 2018

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The majority of viral-cellular fusion transcripts in cervical carcinomas cotranscribe cellular sequences of known or predicted genes

27 July 2018

1 reference

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The identification of microRNAs in a genomically unstable region of human chromosome 8q24.

27 July 2018

1 reference

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Multiple loci identified in a genome-wide association study of prostate cancer

27 July 2018

1 reference

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8q24 and prostate cancer: association with advanced disease and meta-analysis

27 July 2018

1 reference

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Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility

27 July 2018

1 reference

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Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.

27 July 2018

1 reference

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Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes

27 July 2018

1 reference

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The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells.

27 July 2018

1 reference

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Multiple regions within 8q24 independently affect risk for prostate cancer

27 July 2018

1 reference

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Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

27 July 2018

1 reference

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Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study

27 July 2018

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A common variant associated with prostate cancer in European and African populations

27 July 2018

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MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors

27 July 2018

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27 July 2018

The many faces of c-MYC.

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Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis

27 July 2018

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Chimeric transcripts with an open reading frame are generated as a result of translocation to the Pvt-1 region in mouse B-cell tumors

27 July 2018

1 reference

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Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas

27 July 2018

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Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes

27 July 2018

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Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas

27 July 2018

1 reference

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The PVT gene frequently amplifies with MYC in tumor cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Pvt-1 transcripts are found in normal tissues and are altered by reciprocal(6;15) translocations in mouse plasmacytomas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Differences in c-myc and pvt-1 amplification in SEWA sarcoma sublines selected for adherent or non-adherent growth.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Amplification of the c-myc and the pvt-like region in human multiple myeloma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Effects of translocations on transcription from PVT

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

The product of the H19 gene may function as an RNA

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

c-myc amplification is an independent prognostic factor in postmenopausal breast cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

27 July 2018

1 reference

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The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

p53-Dependent induction of PVT1 and miR-1204.

27 July 2018

1 reference

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Chromosome 8q24-Associated Cancers and MYC.

24 September 2018

1 reference

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Genetic susceptibility to sporadic ovarian cancer: a systematic review.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Genome-wide screen identifies PVT1 as a regulator of Gemcitabine sensitivity in human pancreatic cancer cells

24 September 2018

1 reference

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MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence

24 September 2018

1 reference

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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.

24 September 2018

1 reference

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Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

POU5F1P1, a putative cancer susceptibility gene, is overexpressed in prostatic carcinoma

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

A small-cell lung cancer genome with complex signatures of tobacco exposure

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

24 September 2018

1 reference

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Genome-wide association studies in cancer.

24 September 2018

1 reference

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Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

24 September 2018

1 reference

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Multiple loci with different cancer specificities within the 8q24 gene desert

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Multiple newly identified loci associated with prostate cancer susceptibility

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

High-resolution array comparative genomic hybridization of chromosome 8q: evaluation of putative progression markers for gastroesophageal junction adenocarcinomas

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Characterizing the cancer genome in lung adenocarcinoma

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

The Oscar-worthy role of Myc in apoptosis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Quantitative trait loci on chromosome 8q24 for pancreatic beta-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Netwo

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Preferential integration of human papillomavirus type 18 near the c-myc locus in cervical carcinoma.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Identification of a transcriptionally compromised allele of c-MYC in a North American family

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

A polymorphic variant of human c-Myc: Asn11-->Ser.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Translocation of an immunoglobulin kappa locus to a region 3' of an unrearranged c-myc oncogene enhances c-myc transcription

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3339310

Diabetes and Cancer: A Consensus Report

14 November 2018

1 reference

12 December 2020

Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas

1 reference

12 December 2020

Recurrent genomic aberrations combined with deletions of various tumour suppressor genes may deregulate the G1/S transition in CD4+CD56+ haematodermic neoplasms and contribute to the aggressiveness of the disease

1 reference

12 December 2020

Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification

1 reference

12 December 2020

Human papillomavirus genotype as a major determinant of the course of cervical cancer

1 reference

12 December 2020

Variant (6 ; 15) translocation in a murine plasmacytoma occurs near an immunoglobulin κ gene but far from the myc oncogene

1 reference

12 December 2020

Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

1 reference

12 December 2020

Chimeric amplicons containing the c-myc gene in HL60 cells

1 reference

12 December 2020

Identifiers

DOI

10.3389/FGENE.2012.00069

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558003%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558003%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22558003%20AND%20SRC:MED&resulttype=core&format=json