Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia (Q35918060)

11 August 2017

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title

Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia (English)

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11 August 2017

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Pallis M

1

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PubMed ID

15483678

11 August 2017

Russell N

series ordinal

2

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11 August 2017

1 December 2004

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11 August 2017

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11 August 2017

18

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11 August 2017

1927-1930

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11 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403511

11 August 2017

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cites work

P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

P-glycoprotein and terminal transferase expression identify prognostic subsets within cytogenetic risk classes in acute myeloid leukemia.

21 January 2018

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Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.

21 January 2018

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The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

Anti-P-glycoprotein antibody-induced apoptosis of activated peripheral blood lymphocytes: a possible role of P-glycoprotein in lymphocyte survival

21 January 2018

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Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences

21 January 2018

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Retroviral transfection of Madin-Darby canine kidney cells with human MDR1 results in a major increase in globotriaosylceramide and 10(5)- to 10(6)-fold increased cell sensitivity to verocytotoxin. Role of p-glycoprotein in glycolipid synthesis

21 January 2018

1 reference

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The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane

21 January 2018

1 reference

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Accumulation of glucosylceramides in multidrug-resistant cancer cells

21 January 2018

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Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

21 January 2018

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

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NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis

21 January 2018

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Preferential induction of apoptosis for primary human leukemic stem cells

21 January 2018

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Protein kinase Czeta mediated Raf-1/extracellular-regulated kinase activation by daunorubicin

21 January 2018

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Quinine improves the results of intensive chemotherapy in myelodysplastic syndromes expressing P glycoprotein: results of a randomized study.

21 January 2018

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Quinine as a multidrug resistance inhibitor: a phase 3 multicentric randomized study in adult de novo acute myelogenous leukemia

21 January 2018

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Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

21 January 2018

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Comparison of 'sequential' versus 'standard' chemotherapy as re-induction treatment, with or without cyclosporine, in refractory/relapsed acute myeloid leukaemia (AML): results of the UK Medical Research Council AML-R trial

21 January 2018

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Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)

21 January 2018

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Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

21 January 2018

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SDZ PSC 833 the drug resistance modulator activates cellular ceramide formation by a pathway independent of P-glycoprotein

21 January 2018

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Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein

21 January 2018

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Multidrug-resistance phenotype and clinical responses to gemtuzumab ozogamicin

21 January 2018

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A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, lovastatin and pravastatin on leukaemic and normal bone marrow progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

ATP-binding cassette transporters are enriched in non-caveolar detergent-insoluble glycosphingolipid-enriched membrane domains (DIGs) in human multidrug-resistant cancer cells

21 January 2018

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Multidrug resistance in leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

A role for P-glycoprotein in regulating cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

Altered sphingolipid metabolism in multidrug-resistant ovarian cancer cells is due to uncoupling of glycolipid biosynthesis in the Golgi apparatus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

Use of standardized flow cytometric determinants of multidrug resistance to analyse response to remission induction chemotherapy in patients with acute myeloblastic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

Contrasting in vitro effects for the combination of fludarabine, cytosine arabinoside (Ara-C) and granulocyte colony-stimulating factor (FLAG) compared with daunorubicin and Ara-C in P-glycoprotein-positive and P-glycoprotein-negative acute myelobla

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403511

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403511

1 reference

11 August 2017

1 reference

PubMed ID

15483678