Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation (Q35914005)

11 August 2017

Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation (English)

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11 August 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26012548%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Shasha Yin

series ordinal

1

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12 June 2020

language of work or name

English

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publication date

26 May 2015

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Molecular and Cellular Biology

11 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26012548%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

35

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12 June 2020

issue

15

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12 June 2020

page(s)

2673-2683

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The autophagy pathway maintained signaling crosstalk with the Keap1-Nrf2 system through p62 in auditory cells under oxidative stress

12 June 2020

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Chemoprevention of dietary digitoflavone on colitis-associated colon tumorigenesis through inducing Nrf2 signaling pathway and inhibition of inflammation

11 July 2018

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Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1

11 July 2018

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Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue

11 July 2018

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The LIR motif - crucial for selective autophagy

11 July 2018

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Keap1 degradation by autophagy for the maintenance of redox homeostasis

11 July 2018

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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

11 July 2018

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11 July 2018

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Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity

11 July 2018

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miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells

11 July 2018

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Bruton's tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages

11 July 2018

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TLR4-mediated autophagy in macrophages is a p62-dependent type of selective autophagy of aggresome-like induced structures (ALIS).

11 July 2018

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Modification of keap1 cysteine residues by sulforaphane

11 July 2018

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Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation

11 July 2018

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Selective autophagy mediated by autophagic adapter proteins

11 July 2018

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Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1.

11 July 2018

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Selective degradation of p62 by autophagy

11 July 2018

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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

11 July 2018

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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

11 July 2018

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

11 July 2018

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Cysteine-based regulation of the CUL3 adaptor protein Keap1

11 July 2018

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A role for ubiquitin in selective autophagy

11 July 2018

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Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation

11 July 2018

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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

11 July 2018

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HO-1 underlies resistance of AML cells to TNF-induced apoptosis

11 July 2018

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The role of TLR activation in inflammation.

11 July 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

11 July 2018

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Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

11 July 2018

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Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

11 July 2018

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

11 July 2018

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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

11 July 2018

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Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C.

11 July 2018

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Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

11 July 2018

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

11 July 2018

1 reference

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Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

Toll-like receptor signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524114

MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cell proliferation and fibrosis

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26012548

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12 December 2020

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Identifiers

DOI

10.1128/MCB.00105-15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26012548%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26012548%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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