Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury (Q35906957)

11 August 2017

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title

Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury (English)

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11 August 2017

traumatic brain injury

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author name string

Robert Vink

series ordinal

1

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11 August 2017

Corinna Van Den Heuvel

series ordinal

2

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11 August 2017

language of work or name

English

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publication date

1 October 2004

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Expert Opinion on Investigational Drugs

11 August 2017

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11 August 2017

13

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11 August 2017

10

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11 August 2017

1263-1274

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Severe traumatic brain injury

11 August 2017

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https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Neuroprotective agents in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Clinical trials in head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Critical appraisal of neuroprotection trials in head injury: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Novel therapies in development for the treatment of traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Traumatic brain injury: developmental differences in glutamate receptor response and the impact on treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Free radical pathways in CNS injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Oxidative stress in closed-head injury: brain antioxidant capacity as an indicator of functional outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Importance of pharmacologic considerations in the evaluation of new treatments for acute spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Monitoring of reactive oxygen species production after traumatic brain injury in rats with microdialysis and the 4-hydroxybenzoic acid trapping method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Mitochondrial function in apoptotic neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Brain-derived respiring mitochondria exhibit homogeneous, complete and cyclosporin-sensitive permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Mitochondrial participation in ischemic and traumatic neural cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Mechanisms of neuronal death and neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Induced mitochondrial failure in the feline brain: implications for understanding acute post-traumatic metabolic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Increased cerebrospinal fluid glutamate and taurine concentrations are associated with traumatic brain edema formation in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Allopregnanolone (THP) mediates anesthetic effects of progesterone in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Role of progesterone in peripheral nerve repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Cellular basis for progesterone neuroprotection in the injured spinal cord.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Gender-specific impairment on Morris water maze task after entorhinal cortex lesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone protects against lipid peroxidation following traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Administration of progesterone after trauma and hemorrhagic shock prevents hepatocellular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Progesterone administration after trauma and hemorrhagic shock improves cardiovascular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

A nonpsychotropic cannabinoid, HU-211, has cerebroprotective effects after closed head injury in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Cannabinoids and brain injury: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Effect of high-dose dexamethasone on outcome from severe head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

High-dose glucocorticoid treatment improves neurological recovery in head-injured mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Dexamethasone Prevents Hypoxic-Ischemic Brain Damage in the Neonatal Rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Neurogenic inflammation is associated with development of edema and functional deficits following traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Effects of dexamethasone on K(+)-evoked glutamate release from rat hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

A novel brain trauma model in the mouse: effects of dexamethasone treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Blood-free magnesium concentration declines following graded experimental traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Monitoring of serum ionized magnesium in neurosurgical intensive care unit: preliminary results.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Hypomagnesemia after aneurysmal subarachnoid hemorrhage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Magnesium therapy after aneurysmal subarachnoid haemorrhage a dose-finding study for long term treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Subdural hematoma following traumatic brain injury causes a secondary decline in brain free magnesium concentration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

The behavioral effects of magnesium therapy on recovery of function following bilateral anterior medial cortex lesions in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Magnesium pre-treatment reduces neuronal apoptosis in newborn rats in hypoxia-ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

The Effects of Systemic Magnesium Sulfate Infusion on Brain Magnesium Concentrations and Energy State During Hypoxia-Ischemia in Newborn Miniswine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

A molecular basis for the efficacy of magnesium treatment following traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Role of mitochondrial permeability transition in fetal brain damage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Molecular mechanisms of neuroprotective action of immunosuppressants--facts and hypotheses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Neuroprotection by cyclosporin A following transient brain ischemia correlates with the inhibition of the early efflux of cytochrome C to cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Cyclosporin A prevents calpain activation despite increased intracellular calcium concentrations, as well as translocation of apoptosis-inducing factor, cytochrome c and caspase-3 activation in neurons exposed to transient hypoglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Differential response of neural cells to trauma-induced free radical production in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Protection provided by cyclosporin A against excitotoxic neuronal death is genotype dependent

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Dose-response of cyclosporin A in attenuating traumatic axonal injury in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

The immunophilin ligand FK506 attenuates the axonal damage associated with rapid rewarming following posttraumatic hypothermia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.10.1263

10.1517/13543784.13.10.1263

21 January 2018

Identifiers

DOI

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release_ymedrnbjg5ctlni6ljl7vawpri

11 August 2017

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