Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function. (Q35889716)

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4 November 2019

title

Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function (English)

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4 November 2019

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L R Bonin

1

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4 November 2019

J K McDougall

series ordinal

2

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4 November 2019

language of work or name

English

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publication date

1 August 1997

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4 November 2019

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4 November 2019

volume

71

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4 November 2019

issue

8

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4 November 2019

page(s)

5861-5870

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The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter.

4 November 2019

cites work

1 reference

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A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation

11 July 2018

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Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1.

11 July 2018

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CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter.

11 July 2018

1 reference

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Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression

11 July 2018

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mdm2 expression is induced by wild type p53 activity

11 July 2018

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Direct interaction of the human cytomegalovirus IE86 protein with the cis repression signal does not preclude TBP from binding to the TATA box.

11 July 2018

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Cytomegalovirus infection enhances smooth muscle cell proliferation and intimal thickening of rat aortic allografts

11 July 2018

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11 July 2018

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The p53-mdm-2 autoregulatory feedback loop

11 July 2018

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WAF1, a potential mediator of p53 tumor suppression

11 July 2018

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

11 July 2018

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Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.

11 July 2018

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Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

11 July 2018

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Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein.

11 July 2018

1 reference

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Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

11 July 2018

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Induction of WAF1/CIP1 by a p53-independent pathway

11 July 2018

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CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early protein

11 July 2018

1 reference

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Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

11 July 2018

1 reference

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Different roles for cyclins D1 and E in regulation of the G1-to-S transition

11 July 2018

1 reference

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The retinoblastoma gene product negatively regulates transcriptional activation mediated by the human cytomegalovirus IE2 protein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

The retinoblastoma protein and cell cycle control

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Epstein-Barr virus EBNA-LP and transcription regulation properties of pRB, p107 and p53 in transfection assays.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Human cytomegalovirus IE1 and IE2 proteins block apoptosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

11 July 2018

1 reference

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Design of retrovirus vectors for transfer and expression of the human beta-globin gene.

11 July 2018

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Oligomerization of oncoprotein p53.

11 July 2018

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Molecular biology and immunology of cytomegalovirus

11 July 2018

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Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Participation of two human cytomegalovirus immediate early gene regions in transcriptional activation of adenovirus promoters

11 July 2018

1 reference

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Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

11 July 2018

1 reference

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The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and nonatherosclerotic patients

11 July 2018

1 reference

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Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Improved method for computing potential doubling time from flow cytometric data

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Molecular biology of cytomegalovirus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II

11 July 2018

1 reference

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Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Promoter-specific trans activation and repression by human cytomegalovirus immediate-early proteins involves common and unique protein domains

11 July 2018

1 reference

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Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

11 July 2018

1 reference

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High prevalence of latently present cytomegalovirus in arterial walls of patients suffering from grade III atherosclerosis

11 July 2018

1 reference

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Participation of p53 protein in the cellular response to DNA damage

11 July 2018

1 reference

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Epithelial cells immortalized by human papillomaviruses have premalignant characteristics in organotypic culture

11 July 2018

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Cytomegalovirus nucleic acid distribution within the human vascular tree

11 July 2018

1 reference

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A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start site

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

An isoform variant of the cytomegalovirus immediate-early auto repressor functions as a transcriptional activator

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191841

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

11 July 2018

1 reference

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

24 September 2018

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Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus

24 September 2018

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12 December 2020

The immediate early genes of human cytomegalovirus upregulate expression of the interleukin-2 and interleukin-2 receptor genes

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Cytomegalovirus/herpesvirus and carotid atherosclerosis: the ARIC Study

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12 December 2020

Cytomegalovirus DNA in arterial walls of patients with atherosclerosis

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12 December 2020

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis

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12 December 2020

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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12 December 2020

10.1128/JVI.71.8.5861-5870.1997

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9223475%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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