Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction (Q35887748)

10 August 2017

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction (English)

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10 August 2017

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15

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10 June 2020

Kamyar Hadian

2

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10 June 2020

Ana C Messias

3

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10 June 2020

Dierk Niessing

13

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10 June 2020

Daniel Krappmann

16

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10 June 2020

10

Daniel Nagel

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10 June 2020

1

Michelle Vincendeau

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10 June 2020

6

Richard Griesbach

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10 June 2020

4

Jara K Brenke

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10 June 2020

author name string

Jenny Halander

5

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10 June 2020

Ute Greczmiel

7

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10 June 2020

Arianna Bertossi

8

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10 June 2020

Ralf Stehle

9

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10 June 2020

Katrin Demski

11

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10 June 2020

Hana Velvarska

12

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10 June 2020

Arie Geerlof

14

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10 June 2020

language of work or name

English

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publication date

7 January 2016

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10 August 2017

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10 June 2020

volume

6

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10 June 2020

page(s)

18934

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Creative Commons Attribution 4.0 International

10 June 2020

copyright license

start time

7 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/srep18934

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cites work

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Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling

11 July 2018

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Covalent modification of the NF-κB essential modulator (NEMO) by a chemical compound can regulate its ubiquitin binding properties in vitro

11 July 2018

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A catalytic-independent role for the LUBAC in NF-κB activation upon antigen receptor engagement and in lymphoma cells.

11 July 2018

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Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms

11 July 2018

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TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures

11 July 2018

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The IκB kinase complex in NF-κB regulation and beyond

11 July 2018

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Molecular control of the NEMO family of ubiquitin-binding proteins

11 July 2018

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Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.

11 July 2018

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Molecular basis of NF-κB signaling

11 July 2018

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11 July 2018

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Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

11 July 2018

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Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells

11 July 2018

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NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.

11 July 2018

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Structure of a compact conformation of linear diubiquitin

11 July 2018

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Crosstalk in NF-κB signaling pathways

11 July 2018

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New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

11 July 2018

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NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation

11 July 2018

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Crystal structure of inhibitor of κB kinase β

11 July 2018

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Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

11 July 2018

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Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation

11 July 2018

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Constitutive canonical NF-κB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell-like diffuse large cell lymphoma

11 July 2018

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c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

11 July 2018

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11 July 2018

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

11 July 2018

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DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding

11 July 2018

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A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

11 July 2018

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Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin

11 July 2018

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NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain

11 July 2018

1 reference

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Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

11 July 2018

1 reference

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Structural Basis for Recognition of Diubiquitins by NEMO

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Shared principles in NF-kappaB signaling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Direct inhibition of NF-κB activation by peptide targeting the NOA ubiquitin binding domain of NEMO.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Alterations of the IKBKG locus and diseases: an update and a report of 13 novel mutations

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4703965

Prostate stem cell antigen is overexpressed in prostate cancer metastases

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP18934

MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26740240

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SREP18934

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740240%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740240%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26740240%20AND%20SRC:MED&resulttype=core&format=json