8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. (Q35878817)

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3 March 2020

title

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells (English)

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1

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Timothy M. Dore

12

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3 March 2020

author name string

Shahienaz E Hampton

2

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3 March 2020

Louise Ashall

3

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Emily R Hildebrandt

4

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Robert A Kutlik

5

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3 March 2020

Surya P Manandhar

6

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3 March 2020

Brandon J Floyd

7

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Haley E Smith

8

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Jonathan K Dozier

9

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Mark D Distefano

10

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Walter K Schmidt

11

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language of work or name

English

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publication date

30 November 2015

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Bioorganic & Medicinal Chemistry

3 March 2020

published in

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volume

24

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page(s)

160-178

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issue

2

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RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?

3 March 2020

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Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.

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Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

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Chemical inhibition of CaaX protease activity disrupts yeast Ras localization

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

11 July 2018

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Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p

11 July 2018

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Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

11 July 2018

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Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease

11 July 2018

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Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

11 July 2018

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Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

11 July 2018

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

11 July 2018

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11 July 2018

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

11 July 2018

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11 July 2018

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11 July 2018

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24 September 2018

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Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting

24 September 2018

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24 September 2018

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12 December 2020

10.1016/J.BMC.2015.11.043

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