Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy (Q35874392)

10 August 2017

Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy (English)

1 reference

10 August 2017

Marisa Carbonaro

1

1 reference

10 August 2017

Daniel Escuin

2

1 reference

10 August 2017

Aurora O'Brate

3

1 reference

10 August 2017

Maria Thadani-Mulero

4

1 reference

10 August 2017

Paraskevi Giannakakou

5

1 reference

10 August 2017

language of work or name

English

0 references

publication date

24 February 2012

1 reference

Journal of Biological Chemistry

10 August 2017

1 reference

10 August 2017

287

1 reference

10 August 2017

15

1 reference

10 August 2017

11859-11869

1 reference

Taxane-induced blockade to nuclear accumulation of the androgen receptor predicts clinical responses in metastatic prostate cancer

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Microtubules and resistance to tubulin-binding agents

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Regulators of the cytoplasmic dynein motor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

VHL loss causes spindle misorientation and chromosome instability.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

How do microtubule-targeted drugs work? An overview

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Hypoxia induces class III beta-tubulin gene expression by HIF-1alpha binding to its 3' flanking region

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

pVHL and GSK3beta are components of a primary cilium-maintenance signalling network

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Viral strategies for intracellular trafficking: motors and microtubules

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Regulation of glucocorticoid responsiveness in glaucomatous trabecular meshwork cells by glucocorticoid receptor-beta

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Resistance to the tubulin-binding agents in renal cell carcinoma: no mutations in the class I beta-tubulin gene but changes in tubulin isotype protein expression

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Targeting microtubules for cancer chemotherapy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Exploitation of the HIF axis for cancer therapy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Targeting HIF-1 for cancer therapy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Systemic therapy for renal cell carcinoma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Role of dynactin in endocytic traffic: effects of dynamitin overexpression and colocalization with CLIP-170

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Dynactin is required for microtubule anchoring at centrosomes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Protein targeting to the nuclear pore. What can we learn from plants?

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

Dynein is the motor for retrograde axonal transport of organelles

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

A signal sequence mediates the retrograde transport of proteins from the axon periphery to the cell body and then into the nucleus

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

11 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.345587

Generation of bidirectional hypoxia/HIF-responsive expression vectors to target gene expression to hypoxic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.345587

Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.345587

Nuclear transport of parathyroid hormone (PTH)-related protein is dependent on microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.345587

A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.345587

Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.345587

Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3320934

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22367210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The VHL tumour-suppressor gene paradigm

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22367210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytoplasmic dynein is a minus end-directed motor for membranous organelles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22367210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.345587

1 reference

10 August 2017

1 reference

10 August 2017

1 reference