Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors (Q35868868)

10 August 2017

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors (English)

1 reference

10 August 2017

5

1 reference

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14 June 2020

Lingxue Kong

8

1 reference

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14 June 2020

author name string

Dongxi Xiang

1

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14 June 2020

Conglong Zheng

2

1 reference

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14 June 2020

Shu-Feng Zhou

3

1 reference

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14 June 2020

Shuxi Qiao

4

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14 June 2020

Chunwen Pu

6

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14 June 2020

Yong Li

7

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14 June 2020

Abbas Z Kouzani

9

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14 June 2020

Jia Lin

10

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14 June 2020

Ke Liu

11

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14 June 2020

Lianhong Li

12

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14 June 2020

Sarah Shigdar

13

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14 June 2020

Wei Duan

14

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14 June 2020

publication date

2 July 2015

1 reference

10 August 2017

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14 June 2020

volume

5

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14 June 2020

issue

10

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14 June 2020

page(s)

1083-1097

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Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine

14 June 2020

cites work

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Specific and sensitive tumor imaging using biostable oligonucleotide aptamer probes

11 July 2018

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Clinical applications of nucleic acid aptamers in cancer

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11 July 2018

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Aptamers as theranostic agents: modifications, serum stability and functionalisation

11 July 2018

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The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs

11 July 2018

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11 July 2018

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11 July 2018

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Aptamers as targeting delivery devices or anti-cancer drugs for fighting tumors

11 July 2018

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Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates

11 July 2018

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11 July 2018

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Accumulation and toxicity of antibody-targeted doxorubicin-loaded PEG-PE micelles in ovarian cancer cell spheroid model.

11 July 2018

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Size-dependent localization and penetration of ultrasmall gold nanoparticles in cancer cells, multicellular spheroids, and tumors in vivo

11 July 2018

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Modified bases enable high-efficiency oligonucleotide-mediated allelic replacement via mismatch repair evasion

11 July 2018

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Influence of affinity and antigen internalization on the uptake and penetration of Anti-HER2 antibodies in solid tumors

11 July 2018

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Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration

11 July 2018

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RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule

11 July 2018

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Positron emission tomography-computed tomography standardized uptake values in clinical practice and assessing response to therapy

11 July 2018

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BORIS/CTCFL expression is insufficient for cancer-germline antigen gene expression and DNA hypomethylation in ovarian cell lines

11 July 2018

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The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors

11 July 2018

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Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size

11 July 2018

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Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies

11 July 2018

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Engineering lymphocyte subsets: tools, trials and tribulations

11 July 2018

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An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer

11 July 2018

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In silico selection of RNA aptamers

11 July 2018

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Ligand-based targeted therapy for cancer tissue

11 July 2018

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Technical and biological issues relevant to cell typing with aptamers

11 July 2018

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Factors determining antibody distribution in tumors

11 July 2018

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11 July 2018

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11 July 2018

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A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients

11 July 2018

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Drug penetration in solid tumours

11 July 2018

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Development of antibodies and chimeric molecules for cancer immunotherapy

11 July 2018

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Tumor targeting by an aptamer

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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Effect of therapeutic macromolecules in spheroids

11 July 2018

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Developing aptamers into therapeutics

11 July 2018

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Anti-L-selectin aptamers: binding characteristics, pharmacokinetic parameters, and activity against an intravascular target in vivo

11 July 2018

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Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

11 July 2018

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Three-dimensional spheroid model in tumor biology

11 July 2018

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The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

11 July 2018

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Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors

11 July 2018

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A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

11 July 2018

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Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier

11 July 2018

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Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors.

11 July 2018

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Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab.

24 September 2018

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Imaging tumors with an albumin-binding Fab, a novel tumor-targeting agent.

24 September 2018

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The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors.

24 September 2018

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Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation

24 September 2018

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Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms

6 December 2018

1 reference

12 December 2020

Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors

1 reference

12 December 2020

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation

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12 December 2020

Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids

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12 December 2020

Barriers to drug delivery in solid tumors

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12 December 2020

Direct visualization of heterogeneous extravascular distribution of trastuzumab in human epidermal growth factor receptor type 2 overexpressing xenografts

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12 December 2020

Autoradiographic analysis of monoclonal antibody distribution in human colon and breast tumor xenografts

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Approved monoclonal antibodies for cancer therapy

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12 December 2020

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules

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Identifiers

DOI

10.7150/THNO.11711

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26199647%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26199647%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26199647%20AND%20SRC:MED&resulttype=core&format=json