SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell (Q35860498)

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scientific article published on 20 May 2015

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English	SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell	scientific article published on 20 May 2015

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scholarly article

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8 March 2020

SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell (English)

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8 March 2020

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8 March 2020

Hirotaka Watada

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8 March 2020

Carmella Evans-Molina

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Carmella Evans-Molina

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8 March 2020

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Kyoko Fujimaki

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8 March 2020

Takeshi Ogihara

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8 March 2020

Hisanobu Oda

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8 March 2020

Hitoshi Iida

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8 March 2020

Yoshio Fujitani

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8 March 2020

Raghavendra G Mirmira

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20 May 2015

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8 March 2020

Journal of Biological Chemistry

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8 March 2020

290

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8 March 2020

16607-16618

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8 March 2020

Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.

1 reference

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11 July 2018

(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells

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Immune modulation in humans: implications for type 1 diabetes mellitus.

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Lost in translation: endoplasmic reticulum stress and the decline of β-cell health in diabetes mellitus

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Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity.

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11 July 2018

Histone lysine methylation dynamics: establishment, regulation, and biological impact

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Mouse islet of Langerhans isolation using a combination of purified collagenase and neutral protease

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Distinguishing hyperglycemic changes by Set7 in vascular endothelial cells

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Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

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Expression and function of Set7/9 in pancreatic islets

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Regulation of NF-kappaB activity through lysine monomethylation of p65.

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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

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Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit

1 reference

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11 July 2018

Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure

1 reference

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11 July 2018

Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes

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11 July 2018

Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappaB-dependent inflammatory genes. Relevance to diabetes and inflammation

1 reference

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Cytokine signalling in the beta-cell: a dual role for IFNgamma

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Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase

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Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2.

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High-resolution profiling of histone methylations in the human genome

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Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription

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Regulation of p53 activity through lysine methylation

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Gene-specific modulation of TAF10 function by SET9-mediated methylation

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Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation

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Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans

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Islet-associated macrophages in type 2 diabetes.

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Increased number of islet-associated macrophages in type 2 diabetes.

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Differential sensitivity to beta-cell secretagogues in cultured rat pancreatic islets exposed to human interleukin-1 beta

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12 December 2020

based on heuristic

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A common nuclear signal transduction pathway activated by growth factor and cytokine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25995453

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/25995453

12 December 2020

based on heuristic

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10.1074/JBC.M115.661777

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8 March 2020

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8 March 2020

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8 March 2020

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