Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats. (Q35859780)

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7 February 2020

title

Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats (English)

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7 February 2020

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Prabhakara R Nagareddy

1

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7 February 2020

author name string

P S Rajput

2

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7 February 2020

H Vasudevan

3

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7 February 2020

B McClure

4

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7 February 2020

U Kumar

5

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7 February 2020

K M Macleod

6

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J H McNeill

7

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7 February 2020

language of work or name

English

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publication date

1 February 2012

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British Journal of Pharmacology

7 February 2020

published in

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volume

165

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7 February 2020

issue

3

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7 February 2020

page(s)

705-715

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describes a project that uses

7 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Enhanced matrix metalloproteinase activity in the spontaneously hypertensive rat: VEGFR-2 cleavage, endothelial apoptosis, and capillary rarefaction

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Caveolae are a novel pathway for membrane-type 1 matrix metalloproteinase traffic in human endothelial cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

The metabolic syndrome, type 2 diabetes, and cardiovascular disease: understanding the role of insulin resistance.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Impaired endothelial function in arterial hypertension and hypercholesterolemia: potential mechanisms and differences

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Insulin signaling in the arterial wall

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Endothelial dysfunction precedes hypertension in diet-induced insulin resistance.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Regulation of matrix metalloproteinase activity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Fructose-induced insulin resistance and hypertension in rats

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Abnormalities of carbohydrate and lipoprotein metabolism in patients with hypertension. Relationship to obesity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Prevalence of hyperinsulinaemia in patients with high blood pressure

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Vanadyl sulfate prevents fructose-induced hyperinsulinemia and hypertension in rats.

11 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Long-term doxycycline is more effective than atenolol to prevent thoracic aortic aneurysm in marfan syndrome through the inhibition of matrix metalloproteinase-2 and -9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Proteinase activity and receptor cleavage: mechanism for insulin resistance in the spontaneously hypertensive rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Female rats are protected against fructose-induced changes in metabolism and blood pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Chronic N-acetylcysteine prevents fructose-induced insulin resistance and hypertension in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2011.01583.X

Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315042

Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor

24 September 2018

1 reference

12 December 2020

Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction

1 reference

12 December 2020

MMP-2 colocalizes with caveolae on the surface of endothelial cells

1 reference

12 December 2020

Intracellular Action of Matrix Metalloproteinase-2 Accounts for Acute Myocardial Ischemia and Reperfusion Injury

1 reference

12 December 2020

Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro

1 reference

12 December 2020

Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level

1 reference

12 December 2020

Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats

1 reference

12 December 2020

Effect of chronic endothelin blockade in hyperinsulinemic hypertensive rats

1 reference

12 December 2020

Activation of recombinant human neutrophil procollagenase in the presence of doxycycline results in fragmentation of the enzyme and loss of enzyme activity

1 reference

12 December 2020

Defective endothelium-dependent relaxation in fructose-hypertensive rats

1 reference

12 December 2020

Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat

1 reference

12 December 2020

Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms

1 reference

12 December 2020

Epidermal growth factor: a potent vasoconstrictor in experimental hypertension

1 reference

12 December 2020

Gonadectomy prevents endothelial dysfunction in fructose-fed male rats, a factor contributing to the development of hypertension

1 reference

12 December 2020

Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome

1 reference

12 December 2020

10.1111/J.1476-5381.2011.01583.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21740410%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21740410%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21740410

1 reference