A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine) (Q35848202)

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scientific article published on 30 August 2005

Language	Label	Description	Also known as
English	A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)	scientific article published on 30 August 2005

Statements

scholarly article

1 reference

Europe PubMed Central

10 August 2017

A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine) (English)

1 reference

Europe PubMed Central

10 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

Hagop Kantarjian

11

object named as

Hagop Kantarjian

1 reference

Europe PubMed Central

10 August 2017

10

object named as

Stefan Faderl

1 reference

Europe PubMed Central

10 August 2017

William G Wierda

9

object named as

William G Wierda

1 reference

Europe PubMed Central

10 August 2017

William Plunkett

3

object named as

William Plunkett

1 reference

Europe PubMed Central

10 August 2017

8

object named as

Jan Davisson

1 reference

Europe PubMed Central

10 August 2017

7

object named as

Shanta Bantia

1 reference

Europe PubMed Central

10 August 2017

author name string

Varsha Gandhi

1

1 reference

Europe PubMed Central

10 August 2017

John M Kilpatrick

2

1 reference

Europe PubMed Central

10 August 2017

Mary Ayres

4

1 reference

Europe PubMed Central

10 August 2017

Leigh Harman

5

1 reference

Europe PubMed Central

10 August 2017

Min Du

6

1 reference

Europe PubMed Central

10 August 2017

Deborah Thomas

12

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

30 August 2005

1 reference

Europe PubMed Central

10 August 2017

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Europe PubMed Central

10 August 2017

106

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Europe PubMed Central

10 August 2017

13

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Europe PubMed Central

10 August 2017

4253-4260

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Europe PubMed Central

10 August 2017

Crystal structure of human purine nucleoside phosphorylase complexed with acyclovir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Development of transition state analogues of purine nucleoside phosphorylase as anti-T-cell agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Ribonucleotide reductases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

The crystal structure of Escherichia coli purine nucleoside phosphorylase: a comparison with the human enzyme reveals a conserved topology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

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11 July 2018

Bayesian sequential monitoring designs for single-arm clinical trials with multiple outcomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Biochemistry of Diseases of Immunodevelopment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

The metabolism of deoxyguanosine in mitochondria: a characterization of the phosphorylation process which occurs in intact mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Mechanisms of deoxyguanosine toxicity for human T and B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Central nervous system dysfunction and erythrocyte guanosine triphosphate depletion in purine nucleoside phosphorylase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Purine nucleoside phosphorylase deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Abnormal purine metabolism and purine overproduction in a patient deficient in purine nucleoside phosphorylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Purine Nucleoside Phosphorylase Deficiency Associated with Selective Cellular Immunodeficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Partial purification and characterization of deoxyguanosine kinase from pig skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: Possible role of nucleoside kinase(s)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

11 July 2018

Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2′-deoxyguanosine in primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Addition of lithiated 9-deazapurine derivatives to a carbohydrate cyclic imine: convergent synthesis of the aza-C-nucleoside immucillins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Purine nucleoside phosphorylase. Catalytic mechanism and transition-state analysis of the arsenolysis reaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Pre-steady-state transition-state analysis of the hydrolytic reaction catalyzed by purine nucleoside phosphorylase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Inhibition of purine nucleoside phosphorylase by 8-aminoguanosine: selective toxicity for T lymphoblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Selective toxicity of deoxyguanosine and arabinosyl guanine for T-leukemic cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1895256

24 September 2018

Effects of a novel purine nucleoside phosphorylase inhibitor, BCX-34, on activation and proliferation of normal human lymphoid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of peldesine (BCX-34), a purine nucleoside phosphorylase inhibitor, following single and multiple oral doses in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological activity of a novel class of purine nucleoside phosphorylase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine nucleoside phosphorylase: kinetics, mechanism, and specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine nucleoside phosphorylase from human erythrocytes. I. Purification and properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human purine nucleoside phosphorylase. Studies with intact erythrocytes and the purified enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D-arabinofuranosylcytosine therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of deoxyguanosine in intact and fractured mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular pharmacodynamics and plasma pharmacokinetics of parenterally infused hydroxyurea during a phase I clinical trial in chronic myelogenous leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16131572

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2005-03-1309

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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