Recombinant immunotoxins for the treatment of haematological malignancies (Q35842677)

10 August 2017

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title

Recombinant immunotoxins for the treatment of haematological malignancies (English)

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10 August 2017

1

Robert J Kreitman

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PubMed ID

15268678

10 August 2017

language of work or name

English

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publication date

1 July 2004

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Expert Opinion on Biological Therapy

10 August 2017

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10 August 2017

4

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10 August 2017

7

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10 August 2017

1115-1128

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10 August 2017

Cancer statistics, 2004

1 reference

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Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study

21 January 2018

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Radioimmunotherapy with yttrium-90 ibritumomab tiuxetan for patients with relapsed CD20+ B-cell non-Hodgkin's lymphoma

21 January 2018

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Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines.

21 January 2018

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High-pressure-liquid-chromatographic and fluorimetric methods for the determination of adenine released from ribosomes by ricin and gelonin

21 January 2018

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Reconstitution of diphtheria toxin from two nontoxic cross-reacting mutant proteins.

21 January 2018

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Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein

21 January 2018

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Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin

21 January 2018

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Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

21 January 2018

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Structure of exotoxin A of Pseudomonas aeruginosa at 3.0-Angstrom resolution

21 January 2018

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Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story

21 January 2018

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Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.

21 January 2018

1 reference

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Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor

21 January 2018

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A proper amino terminus of diphtheria toxin is important for cytotoxicity

21 January 2018

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Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

21 January 2018

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Purification and characterization of IL6-PE4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin.

21 January 2018

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Production of recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system for biotherapy of GMCSF-receptor positive hematologic malignancies

21 January 2018

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Gene optimization is necessary to express a bivalent anti-human anti-T cell immunotoxin in Pichia pastoris

21 January 2018

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The IL-2/IL-2 receptor system: a current overview

21 January 2018

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Interleukin-2 receptor beta-chain (p70-75) expressed on leukemic cells from adult T cell leukemia patients

21 January 2018

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Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen

21 January 2018

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Biological correlates of acute hypersensitivity events with DAB(389)IL-2 (denileukin diftitox, ONTAK) in cutaneous T-cell lymphoma: decreased frequency and severity with steroid premedication

21 January 2018

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Denileukin diftitox for the treatment of panniculitic lymphoma

21 January 2018

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Arginine butyrate increases the cytotoxicity of DAB(389)IL-2 in leukemia and lymphoma cells by upregulation of IL-2Rbeta gene

21 January 2018

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Immunomodulatory effects of RXR rexinoids: modulation of high-affinity IL-2R expression enhances susceptibility to denileukin diftitox

21 January 2018

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Only high-affinity receptors for interleukin 2 mediate internalization of ligand

21 January 2018

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A recombinant single-chain immunotoxin composed of anti-Tac variable regions and a truncated diphtheria toxin

21 January 2018

1 reference

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Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli

21 January 2018

1 reference

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Targeting Pseudomonas exotoxin to hematologic malignancies

21 January 2018

1 reference

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Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions

21 January 2018

1 reference

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The ligand-binding domain of CD22 is needed for inhibition of the B cell receptor signal, as demonstrated by a novel human CD22-specific inhibitor compound.

21 January 2018

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Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.

21 January 2018

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Identification of CD22 ligands on bone marrow sinusoidal endothelium implicated in CD22-dependent homing of recirculating B cells

21 January 2018

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Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells

21 January 2018

1 reference

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

21 January 2018

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Hairy cell leukemia variant

21 January 2018

1 reference

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The natural history and clinico-pathological features of the variant form of hairy cell leukemia.

21 January 2018

1 reference

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Recombinant anti-CD25 immunotoxin RFT5(SCFV)-ETA' demonstrates successful elimination of disseminated human Hodgkin lymphoma in SCID mice.

21 January 2018

1 reference

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An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4(scFv)-ETA') is a potent immunotoxin against a Hodgkin-derived cell line

21 January 2018

1 reference

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Isolation of new anti-CD30 scFvs from DNA-immunized mice by phage display and biologic activity of recombinant immunotoxins produced by fusion with truncated pseudomonas exotoxin

21 January 2018

1 reference

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An anti-CD3 single-chain immunotoxin with a truncated diphtheria toxin avoids inhibition by pre-existing antibodies in human blood

21 January 2018

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Improved binding of a bivalent single-chain immunotoxin results in increased efficacy for in vivo T-cell depletion

21 January 2018

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Production of anti-CD3 and anti-CD7 ricin A-immunotoxins for a clinical pilot study

21 January 2018

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Therapy of human T-cell acute lymphoblastic leukaemia with a combination of anti-CD7 and anti-CD38-SAPORIN immunotoxins is significantly better than therapy with each individual immunotoxin

21 January 2018

1 reference

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In vitro interleukin-3 binding to leukemia cells predicts cytotoxicity of a diphtheria toxin/IL-3 fusion protein.

21 January 2018

1 reference

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High affinity interleukin-3 receptor expression on blasts from patients with acute myelogenous leukemia correlates with cytotoxicity of a diphtheria toxin/IL-3 fusion protein.

21 January 2018

1 reference

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Diphtheria toxin-interleukin-3 fusion protein (DT(388)IL3) prolongs disease-free survival of leukemic immunocompromised mice

21 January 2018

1 reference

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Expression and purification of the recombinant diphtheria fusion toxin DT388IL3 for phase I clinical trials

21 January 2018

1 reference

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A urokinase receptor mRNA binding protein-mRNA interaction regulates receptor expression and function in human pleural mesothelioma cells

21 January 2018

1 reference

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The diphtheria toxin/urokinase fusion protein (DTAT) is selectively toxic to CD87 expressing leukemic cells.

21 January 2018

1 reference

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Targeting urokinase-type plasminogen activator receptor on human glioblastoma tumors with diphtheria toxin fusion protein DTAT.

21 January 2018

1 reference

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Targeting the over-expressed urokinase-type plasminogen activator receptor on glioblastoma multiforme

21 January 2018

1 reference

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Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin

21 January 2018

1 reference

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10.1517/14712598.4.7.1115

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15268678