Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments. (Q35841910)

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21 January 2020

title

Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments (English)

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21 January 2020

3

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21 January 2020

author name string

Lei Gu

series ordinal

1

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21 January 2020

Sam Ngo

series ordinal

2

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21 January 2020

language of work or name

English

0 references

publication date

25 January 2012

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Journal of Biological Chemistry

21 January 2020

published in

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21 January 2020

volume

287

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21 January 2020

issue

12

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21 January 2020

page(s)

9081-9089

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A partially folded structure of amyloid-beta(1-40) in an aqueous environment

21 January 2020

cites work

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High-pressure EPR reveals conformational equilibria and volumetric properties of spin-labeled proteins

11 July 2018

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Atomic-level characterization of the ensemble of the Aβ(1-42) monomer in water using unbiased molecular dynamics simulations and spectral algorithms

11 July 2018

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Monitoring Alzheimer Amyloid Peptide Aggregation by EPR

11 July 2018

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Structural characterization of beta-amyloid oligomer-aggregates by ion mobility mass spectrometry and electron spin resonance spectroscopy

11 July 2018

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Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins

11 July 2018

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Amyloid beta-protein monomer folding: free-energy surfaces reveal alloform-specific differences

11 July 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

11 July 2018

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Structural determinants of nitroxide motion in spin-labeled proteins: Solvent-exposed sites in helix B of T4 lysozyme

11 July 2018

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Methods and applications of site-directed spin labeling EPR spectroscopy.

11 July 2018

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Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus

11 July 2018

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Structural determinants of nitroxide motion in spin-labeled proteins: Tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme

11 July 2018

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The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

11 July 2018

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A beta oligomers - a decade of discovery

11 July 2018

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Recent advances and applications of site-directed spin labeling.

11 July 2018

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15N relaxation study of the amyloid beta-peptide: structural propensities and persistence length

11 July 2018

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Amyloid beta-protein monomer structure: a computational and experimental study.

11 July 2018

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Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

11 July 2018

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On the nucleation of amyloid beta-protein monomer folding

11 July 2018

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

11 July 2018

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Random-coil behavior and the dimensions of chemically unfolded proteins

11 July 2018

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Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure

11 July 2018

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Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

11 July 2018

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A new spin on protein dynamics

11 July 2018

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

11 July 2018

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NMR studies in aqueous solution fail to identify significant conformational differences between the monomeric forms of two Alzheimer peptides with widely different plaque-competence, A beta(1-40)(ox) and A beta(1-42)(ox).

11 July 2018

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A mathematical model of the kinetics of beta-amyloid fibril growth from the denatured state

11 July 2018

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The Alzheimer's peptide a beta adopts a collapsed coil structure in water

11 July 2018

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Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl alpha-chymotrypsin using different denaturants

11 July 2018

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Evidence that A beta 42 is the real culprit in Alzheimer's disease.

11 July 2018

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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

21 January 2018

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Characterizations of distinct amyloidogenic conformations of the Abeta (1-40) and (1-42) peptides.

21 January 2018

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Abeta42 is more rigid than Abeta40 at the C terminus: implications for Abeta aggregation and toxicity.

21 January 2018

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Preparation of amyloid beta-protein for structural and functional studies

21 January 2018

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Biofunctionalized polymer surfaces exhibiting minimal interaction towards immobilized proteins.

21 January 2018

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Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

21 January 2018

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Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.

21 January 2018

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Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease.

21 January 2018

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Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure

21 January 2018

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His-tag impact on structure.

21 January 2018

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Oriented versus random protein immobilization

21 January 2018

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Translational, rotational and internal dynamics of amyloid beta-peptides (Abeta40 and Abeta42) from molecular dynamics simulations.

21 January 2018

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Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

21 January 2018

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A Single-Molecule Study of RNA Catalysis and Folding

21 January 2018

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Distinct Morphologies for Amyloid Beta Protein Monomer: Aβ1–40, Aβ1–42, and Aβ1–40(D23N)

21 January 2018

1 reference

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Viscosity and density of aqueous solutions of urea and guanidine hydrochloride

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22277652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural, dynamic properties of key residues in Abeta amyloidogenesis: implications of an important role of nanosecond timescale dynamics

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22277652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Methyl dynamics of the amyloid-beta peptides Abeta40 and Abeta42

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22277652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.292086

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22277652%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22277652%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22277652%20AND%20SRC:MED&resulttype=core&format=json