Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice (Q35839992)

10 August 2017

Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice (English)

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10 August 2017

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14

Pierre Corvol

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Kenneth Bernstein

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object named as

Kenneth E Bernstein

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10 August 2017

Sophie Conchon

6

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author name string

Sandrine Billet

1

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10 August 2017

Sabine Bardin

2

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10 August 2017

Sonia Verp

3

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10 August 2017

Véronique Baudrie

4

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10 August 2017

Annie Michaud

5

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10 August 2017

Martine Muffat-Joly

7

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10 August 2017

Brigitte Escoubet

8

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10 August 2017

Evelyne Souil

9

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10 August 2017

Ghislaine Hamard

10

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10 August 2017

Jean Marie Gasc

12

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10 August 2017

Jean-Luc Elghozi

13

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10 August 2017

Eric Clauser

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10 August 2017

language of work or name

English

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publication date

1 July 2007

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Journal of Clinical Investigation

10 August 2017

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10 August 2017

117

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10 August 2017

7

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10 August 2017

1914-1925

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Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Low renin hypertensive states: perspectives, unsolved problems, future research

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Peptide and nonpeptide antagonist interaction with constitutively active human AT1 receptors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonists

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Alteration of cardiac and renal functions in transgenic mice overexpressing human mineralocorticoid receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Insights into the functions of type 1 (AT1) angiotensin II receptors provided by gene targeting

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Systematic identification of mutations that constitutively activate the angiotensin II type 1A receptor by screening a randomly mutated cDNA library with an original pharmacological bioassay

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Abnormal water metabolism in mice lacking the type 1A receptor for ANG II.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Regulation of blood pressure by the type 1A angiotensin II receptor gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Genetic control of blood pressure and the angiotensinogen locus

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Measurement of renin activity, concentration and substrate in rat plasma by radioimmunoassay of angiotensin I.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Cloning and expression of a novel angiotensin II receptor subtype

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

The AT1A receptor "gain-of-function" mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin II.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Genetics of human hypertension

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Renal growth and development in mice lacking AT1A receptors for angiotensin II.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Targeting deletion of angiotensin type 1B receptor gene in the mouse.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Enhancement of mRNA in situ hybridization signal by microwave heating.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1890996

Absence of angiotensin II type 1 receptor gene mutations in human adrenal tumors

24 September 2018

1 reference

12 December 2020

A noninternalized nondesensitized truncated AT1A receptor transduces an amplified ANG II signal

1 reference

12 December 2020

Angiotensinogen modulates renal vasculature growth

1 reference

12 December 2020

Physiological impact of increased expression of the AT1 angiotensin receptor

1 reference

12 December 2020

A direct determination of plasma aldosterone

1 reference

12 December 2020

Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene

1 reference

12 December 2020

Tissular expression and regulation of type 1 angiotensin II receptor subtypes by quantitative reverse transcriptase-polymerase chain reaction analysis

1 reference

12 December 2020

Male–female differences in fertility and blood pressure in ACE-deficient mice

1 reference

12 December 2020

Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects

1 reference

12 December 2020

Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone

1 reference

12 December 2020

Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia

1 reference

12 December 2020

Targeted inactivation of the Ren-2 gene in mice

1 reference

12 December 2020

Somatic mutations of the angiotensin II (AT1) receptor gene are not present in aldosterone-producing adenoma

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI28764

1 reference

10 August 2017

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10 August 2017

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