Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins (Q35836514)

10 August 2017

Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins (English)

1 reference

10 August 2017

1 reference

1

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6 June 2020

Dong Yang

2

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6 June 2020

Guohui Pan

4

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6 June 2020

5

Wensheng Xiang

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6 June 2020

author name string

Yijun Yan

3

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6 June 2020

Ben Shen

6

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6 June 2020

language of work or name

English

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publication date

10 November 2015

1 reference

Applied Microbiology and Biotechnology

10 August 2017

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6 June 2020

volume

100

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6 June 2020

issue

5

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6 June 2020

page(s)

2267-2277

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https://scigraph.springernature.com/pub.10.1007/s00253-015-7119-7

6 June 2020

exact match

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cites work

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Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

11 July 2018

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Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase

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Molecular regulation of antibiotic biosynthesis in streptomyces.

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Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators.

11 July 2018

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The pleitropic regulator AdpAch is required for natamycin biosynthesis and morphological differentiation in Streptomyces chattanoogensis.

11 July 2018

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Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141.

11 July 2018

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Multifaceted modes of action for the glutarimide-containing polyketides revealed

11 July 2018

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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

11 July 2018

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Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

11 July 2018

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iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

11 July 2018

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polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis.

11 July 2018

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Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

11 July 2018

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Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins

11 July 2018

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Engineered production of iso-migrastatin in heterologous Streptomyces hosts

11 July 2018

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Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

11 July 2018

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Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts

11 July 2018

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Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds

11 July 2018

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11 July 2018

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Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis

11 July 2018

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Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster

11 July 2018

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11 July 2018

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11 July 2018

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Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities

11 July 2018

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11 July 2018

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A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds

11 July 2018

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11 July 2018

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11 July 2018

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11 July 2018

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TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants

11 July 2018

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Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius

11 July 2018

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11 July 2018

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Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity

11 July 2018

1 reference

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Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4758858

SanG, a transcriptional activator, controls nikkomycin biosynthesis through binding to the sanN-sanO intergenic region in Streptomyces ansochromogenes

24 September 2018

1 reference

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AfsR recruits RNA polymerase to the afsS promoter: a model for transcriptional activation by SARPs.

24 September 2018

1 reference

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A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development

24 September 2018

1 reference

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Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4758858

High-yield actinorhodin production in fed-batch culture by a Streptomyces lividans strain overexpressing the pathway-specific activator gene actll-ORF4.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4758858

pIJ101, a multi-copy broad host-range Streptomyces plasmid: Functional analysis and development of DNA cloning vectors

24 September 2018

1 reference

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A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold

24 September 2018

1 reference

12 December 2020

NK30424A and B, novel inhibitors of lipopolysaccharide-induced tumour necrosis factor alpha production, produced by Streptomyces sp. NA30424

1 reference

12 December 2020

The structure and chemistry of actidione, an antibiotic from Streptomyces griseus

1 reference

12 December 2020

Actidione, an antibiotic from Streptomyces griseus

1 reference

12 December 2020

Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.1130

Identifiers

DOI

10.1007/S00253-015-7119-7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26552797%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26552797%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26552797%20AND%20SRC:MED&resulttype=core&format=json