Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex (Q35832641)

10 August 2017

Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex (English)

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10 August 2017

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Nicholas Rensing

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10 August 2017

Lirong Han

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10 August 2017

Michael Wong

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3

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10 August 2017

29 June 2015

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56

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1088-1097

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describes a project that uses

10 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4496285/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials

1 reference

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Adverse events associated with mTOR inhibitors

27 July 2018

1 reference

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Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats

27 July 2018

1 reference

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The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice

27 July 2018

1 reference

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Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

27 July 2018

1 reference

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Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin.

27 July 2018

1 reference

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Therapeutic value of prenatal rapamycin treatment in a mouse brain model of tuberous sclerosis complex.

27 July 2018

1 reference

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Randomized, blinded trial of weekend vs daily prednisone in Duchenne muscular dystrophy

27 July 2018

1 reference

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Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

27 July 2018

1 reference

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The natural history of epilepsy in tuberous sclerosis complex

27 July 2018

1 reference

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Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

27 July 2018

1 reference

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Preventing and treating posttraumatic seizures: the human experience

27 July 2018

1 reference

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Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function

27 July 2018

1 reference

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

27 July 2018

1 reference

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Clinical presentation and diagnosis of tuberous sclerosis complex in infancy

27 July 2018

1 reference

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Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons

27 July 2018

1 reference

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Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

27 July 2018

1 reference

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Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

Rapamycin: brain excitability studied in vitro.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496285

24 September 2018

Identifiers

DOI

10.1111/EPI.13031

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10 August 2017

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10 August 2017

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