Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide (Q35827146)

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scientific article published in August 2005

Language	Label	Description	Also known as
English	Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide	scientific article published in August 2005

Statements

scholarly article

1 reference

Europe PubMed Central

10 August 2017

Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide (English)

1 reference

Europe PubMed Central

10 August 2017

0 references

pharmacokinetics

1 reference

based on heuristic

inferred from title

object named as

Mikko Neuvonen

4

0 references

object named as

Mikko Niemi

1

0 references

object named as

Janne T Backman

2

0 references

Pertti J. Neuvonen

object named as

Pertti J Neuvonen

5

0 references

Laura Juntti-Patinen

3

object named as

Laura Juntti-Patinen

1 reference

Europe PubMed Central

10 August 2017

language of work or name

0 references

publication date

1 August 2005

1 reference

Europe PubMed Central

10 August 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

10 August 2017

60

1 reference

Europe PubMed Central

10 August 2017

208-217

1 reference

Europe PubMed Central

10 August 2017

2

1 reference

Europe PubMed Central

10 August 2017

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Importance of P-glycoprotein at blood-tissue barriers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Clinical pharmacokinetics of nateglinide: a rapidly-absorbed, short-acting insulinotropic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Effect of rifampicin on the pharmacokinetics and pharmacodynamics of nateglinide in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

CYP2C8 and CYP3A4 are the principal enzymes involved in the human in vitro biotransformation of the insulin secretagogue repaglinide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Crystal structure of human cytochrome P450 2C9 with bound warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Gemfibrozil greatly increases plasma concentrations of cerivastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Clinical pharmacokinetics and pharmacodynamics of repaglinide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Interaction of common azole antifungals with P glycoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

The xenobiotic inhibitor profile of cytochrome P4502C8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Rifampin decreases the plasma concentrations and effects of repaglinide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Clinical pharmacokinetics of fibric acid derivatives (fibrates).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Influence of albumin on itraconazole and ketoconazole antifungal activity: results of a dynamic in vitro study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

11 July 2018

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2005.02385.X

21 January 2018

Effects of fluconazole and fluvoxamine on the pharmacokinetics and pharmacodynamics of glimepiride

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2005.02385.X

21 January 2018

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2005.02385.X

21 January 2018

Effect of fluconazole on the pharmacokinetics and pharmacodynamics of nateglinide

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2005.02385.X

21 January 2018

Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2005.02385.X

21 January 2018

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2005.02385.X

21 January 2018

Influence of CYP2C9 and CYP2D6 polymorphisms on the pharmacokinetics of nateglinide in genotyped healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

24 September 2018

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

24 September 2018

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of glimepiride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

24 September 2018

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

24 September 2018

Pharmacokinetics and metabolism of nateglinide in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1884918

24 September 2018

Determination of gemfibrozil in plasma by high performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

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Assay of itraconazole in leukemic patient plasma by reversed-phase small-bore liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of itraconazole in serum with high-performance liquid chromatography and fluorescence detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terfenadine metabolism in human liver. In vitro inhibition by macrolide antibiotics and azole antifungals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variability in human cytochrome P450 paclitaxel metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

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Disposition of gemfibrozil and gemfibrozil acyl glucuronide in the rat isolated perfused liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

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Structure determination of metabolites isolated from urine and bile after administration of AY4166, a novel D-phenylalanine-derivative hypoglycemic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Itraconazole decreases renal clearance of digoxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic disposition of the acyl glucuronide1-O-gemfibrozil-beta-D-glucuronide: effects of dibromosulfophthalein on membrane transport and aglycone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

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Absorption, metabolism and excretion of a single oral dose of (14)C-repaglinide during repaglinide multiple dosing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of active simvastatin acid are increased by gemfibrozil

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

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inferred from PubMed ID database lookup

Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-beta-D-glucuronide: effects of clofibric acid, acetaminophen, and acetaminophen glucuronide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

12 December 2020

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A significant role of human cytochrome P450 2C8 in amiodarone N-deethylation: an approach to predict the contribution with relative activity factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16042675

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Identifiers

10.1111/J.1365-2125.2005.02385.X

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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