Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically (Q35826855)

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1 November 2019

title

Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically (English)

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1 November 2019

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1

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1 November 2019

Daniela Uberti

6

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Peter Henry St George-Hyslop

1 November 2019

9

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Maurizio Memo

10

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1 November 2019

author name string

Diodato E

2

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1 November 2019

Lozza G

3

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1 November 2019

Brusa R

4

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1 November 2019

Casarini M

5

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1 November 2019

Rozmahel R

7

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Westaway D

8

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1 November 2019

Ongini E

11

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1 November 2019

language of work or name

English

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publication date

1 November 2000

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Proceedings of the National Academy of Sciences of the United States of America

1 November 2019

published in

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1 November 2019

volume

97

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page(s)

12822-12827

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1 November 2019

issue

23

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Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

1 November 2019

cites work

1 reference

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Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

27 July 2018

1 reference

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Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures.

27 July 2018

1 reference

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Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

On the spurious endoproteolytic processing of the presenilin proteins in cultured cells and tissues

27 July 2018

1 reference

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Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

27 July 2018

1 reference

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Light and electron microscopic localization of presenilin-1 in primate brain.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Kainate-induced brain lesion: similar local and remote histopathological and molecular changes as in ischemic brain infarct.

27 July 2018

1 reference

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Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

27 July 2018

1 reference

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

27 July 2018

1 reference

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

27 July 2018

1 reference

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Modification of seizure activity by electrical stimulation. II. Motor seizure

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

N-methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Brain volume estimation from serial section measurements: a comparison of methodologies

27 July 2018

1 reference

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

27 July 2018

1 reference

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

27 July 2018

1 reference

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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.23.12822

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.23.12822

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

21 January 2018

1 reference

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Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.23.12822

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.23.12822

Alterations in tau immunostaining in the rat hippocampus following transient cerebral ischemia.

21 January 2018

1 reference

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The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

21 January 2018

1 reference

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Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations.

21 January 2018

1 reference

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An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

1 reference

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Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.

21 January 2018

1 reference

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Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18848

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

24 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.97.23.12822

21 January 2018

Identifiers

DOI

10.1073/PNAS.97.23.12822

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11070093%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

0 references

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1 November 2019

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