Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice (Q35808725)

10 August 2017

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice (English)

1 reference

10 August 2017

1 reference

Ling-Lei Kong

1

1 reference

10 August 2017

Xiao-Mei Zhuang

2

1 reference

10 August 2017

Hai-Ying Yang

3

1 reference

10 August 2017

Mei Yuan

4

1 reference

10 August 2017

Liang Xu

5

1 reference

10 August 2017

Hua Li

6

1 reference

10 August 2017

language of work or name

English

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publication date

2 July 2015

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10 August 2017

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10 August 2017

5

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10 August 2017

11747

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Creative Commons Attribution 4.0 International

10 August 2017

start time

2 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/srep11747

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cites work

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Excretion of [3H]triptolide and its metabolites in rats after oral administration

11 July 2018

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Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp

11 July 2018

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Triptolide with potential medicinal value for diseases of the central nervous system

11 July 2018

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Gene silencing by chemically modified siRNAs

11 July 2018

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Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes.

11 July 2018

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Virtual Screening with AutoDock: Theory and Practice

11 July 2018

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Recent attempts at RNAi-mediated P-glycoprotein downregulation for reversal of multidrug resistance in cancer

11 July 2018

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Triptolide and its expanding multiple pharmacological functions

11 July 2018

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Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.

11 July 2018

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The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy

11 July 2018

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Ligand docking and binding site analysis with PyMOL and Autodock/Vina

11 July 2018

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Membrane transporters in drug development

11 July 2018

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Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.

11 July 2018

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Scientific and regulatory perspectives on metabolizing enzyme-transporter interplay and its role in drug interactions: challenges in predicting drug interactions

11 July 2018

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Predicting drug-drug interactions: an FDA perspective

11 July 2018

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

11 July 2018

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Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells

11 July 2018

1 reference

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MDR- and CYP3A4-mediated drug-drug interactions

11 July 2018

1 reference

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Small interfering RNA in drug metabolism and transport

11 July 2018

1 reference

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Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

11 July 2018

1 reference

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MDR- and CYP3A4-mediated drug-herbal interactions

11 July 2018

1 reference

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Knocking down transport: applications of RNA interference in the study of drug transport proteins

11 July 2018

1 reference

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Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress

11 July 2018

1 reference

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In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

A portrait of the Bcl-2 protein family: life, death, and the whole picture

11 July 2018

1 reference

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Functional ATP-binding cassette drug efflux transporters in isolated human and rat hepatocytes significantly affect assessment of drug disposition

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Assessment of the roles of P-glycoprotein and cytochrome P450 in triptolide-induced liver toxicity in sandwich-cultured rat hepatocyte model

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Molecular analyses of the Chinese herb Leigongteng (Tripterygium wilfordii Hook.f.).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4488747

"I know what you told me, but this is what I think:" perceived risk of Alzheimer disease among individuals who accurately recall their genetics-based risk estimate

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP11747

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes

21 January 2018

1 reference

12 December 2020

Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats

1 reference

12 December 2020

MDR1a/1b gene silencing enhances drug sensitivity in rat fibroblast-like synoviocytes

1 reference

12 December 2020

P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

1 reference

12 December 2020

Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury

1 reference

12 December 2020

Binding of modulators to mouse and human multidrug resistance P-glycoprotein. A computational study

1 reference

12 December 2020

Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats

1 reference

12 December 2020

Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats.

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP11747

1 reference

10 August 2017

1 reference

10 August 2017

1 reference