The use of 3-D cultures for high-throughput screening: the multicellular spheroid model (Q35801815)

10 August 2017

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title

The use of 3-D cultures for high-throughput screening: the multicellular spheroid model (English)

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10 August 2017

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1

Leoni A Kunz-Schughart

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10 August 2017

James P Freyer

2

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PubMed ID

15191644

10 August 2017

Ferdinand Hofstaedter

series ordinal

3

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PubMed ID

15191644

10 August 2017

Reinhard Ebner

series ordinal

4

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10 August 2017

1 June 2004

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Journal of Biomolecular Screening

10 August 2017

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10 August 2017

9

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10 August 2017

273-285

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10 August 2017

4

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High-throughput screening: new technology for the 21st century

10 August 2017

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https://api.crossref.org/works/10.1177%2F1087057104265040

High-throughput and ultra-high-throughput screening: solution- and cell-based approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Developmental therapeutics program at the NCI: molecular target and drug discovery process

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Flasks, fibres and flanks--pre-clinical tumour models for predicting clinical antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

In vitro prediction of gastrointestinal absorption and bioavailability: an experts' meeting report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Engineering cellular microenvironments to improve cell-based drug testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Cell and environment interactions in tumor microregions: the multicell spheroid model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Tumor biology and experimental therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

The multilayered postconfluent cell culture as a model for drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Design and application of NMR-compatible bioreactor circuits for extended perfusion of high-density mammalian cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Selection of chemotherapy by ex vivo assessment of tumor sensitivity to cytotoxic drugs: results of a clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Organic tissues in rotating bioreactors: fluid‐mechanical aspects, dynamic growth models, and morphological evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Physiological and cell biological aspects of perfusion culture technique employed to generate differentiated tissues for long term biomaterial testing and tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Advanced technique for long term culture of epithelia in a continuous luminal-basal medium gradient

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

A tissue-like culture system using microstructures: influence of extracellular matrix material on cell adhesion and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Further development of microstructured culture systems and their use in tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Mechanisms for monocyte activation in co-culture with autologous tumor spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

The organizing principle: microenvironmental influences in the normal and malignant breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Multicellular spheroids. A review on cellular aggregates in cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Three-dimensional spheroid model in tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Multicellular resistance: a paradigm for clinical resistance?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

A gene therapy/targeted radiotherapy strategy for radiation cell kill by.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Transfectant mosaic spheroids: a new model for evaluation of tumour cell killing in targeted radiotherapy and experimental gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Experimental targeted radioiodide therapy following transfection of the sodium iodide symporter gene: effect on clonogenicity in both two-and three-dimensional models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Spheroids in radiobiology and photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Radioimmunotherapy of prostatic adenocarcinomas: effects of 131I-labelled E4 antibodies on cells at different depth in DU 145 spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Analysis of growth of multicellular tumour spheroids by mathematical models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Drug and radiation resistance in spheroids: cell contact and kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Effect of therapeutic macromolecules in spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Multicellular tumour spheroids in radiation biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Three-dimensional cultures of prostatic cells: tissue models for the development of novel anti-cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Three-dimensional spheroid cultures of human prostate cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Forecasting the growth of multicell tumour spheroids: implications for the dynamic growth of solid tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Effect of polarity and differentiation on antibody localization in multicellular tumour spheroid and xenograft models and its potential importance for in vivo immunotargeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Automated selective dissociation of cells from different regions of multicellular spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Regrowth kinetics of cells from different regions of multicellular spheroids of four cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Solid stress generated by spheroid growth estimated using a linear poroelasticity model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Tumor-associated fibroblasts recruit blood monocytes into tumor tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Spheroids: relation between tumour and endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Cytokine repertoire during maturation of monocytes to macrophages within spheroids of malignant and non-malignant urothelial cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Autologous spheroid culture: a screening tool for human brain tumour invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Response to BCNU of spheroids grown from mixtures of drug-sensitive and drug-resistant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Identification of genes expressed in tumor-associated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Diffusion and binding of monoclonal antibody TNT-1 in multicellular tumor spheroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Structural polarity and functional bile canaliculi in rat hepatocyte spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Hepatocyte polarity and the peroxisomal compartment: a comparative study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Differentiation and proliferation of primary rat hepatocytes cultured as spheroids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Hepatocyte spheroids: prolonged hepatocyte viability for in vitro modeling of nongenotoxic carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Formation of cartilage-like spheroids by micromass cultures of murine C3H10T1/2 cells upon treatment with transforming growth factor-beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Fucose in alpha(1-6)-linkage regulates proliferation and histogenesis in reaggregated retinal spheroids of the chick embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Hollow-spheres: a new model for analyses of differentiation of pancreatic duct epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Autocrine stimulation of human pancreatic duct-like development by soluble isoforms of epimorphin in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Biohybrid microarrays--impedimetric biosensors with 3D in vitro tissues for toxicological and biomedical screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

ALA- and ALA-hexylester-induced protoporphyrin IX fluorescence and distribution in multicell tumour spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Slow penetration of anthracyclines into spheroids and tumors: a therapeutic advantage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Time-resolved confocal analysis of antibody penetration into living, solid tumor spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Multilayer Primary Epithelial Cell Culture from Bovine Conjunctiva as a Model for in vitro Toxicity Tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Viable sorting of intact multicellular spheroids by flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Tracking cell invasion of human glioma cells and suppression by anti-matrix metalloproteinase agent in rodent brain-slice model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

Unravelling novel intracellular pathways in cell-based assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1087057104265040

21 January 2018

Identifiers

DOI

10.1177/1087057104265040

1 reference

10 August 2017

1 reference

PubMed ID

15191644