Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease (Q35784522)

10 August 2017

Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease (English)

1 reference

10 August 2017

Geoffrey R Hill

14

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Jerome Ritz

Jerome Ritz

20

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Jonathan S. Serody

Jonathan S Serody

12

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Kelli P MacDonald

Kelli P MacDonald

Angela Panoskaltsis-Mortari

4

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9

Angela Panoskaltsis-Mortari

1 reference

10 August 2017

Stefanie Sarantopoulos

23

Stefanie Sarantopoulos

1 reference

10 August 2017

24

Bruce R Blazar

1 reference

10 August 2017

19

Joseph H Antin

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10 August 2017

21

Nelson J Chao

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10 August 2017

18

Robert J Soiffer

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10 August 2017

17

Corey S Cutler

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10 August 2017

16

John Koreth

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10 August 2017

10

Patricia A Taylor

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10 August 2017

3

Leo Luznik

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10 August 2017

15

Ivan Maillard

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10 August 2017

5

Katelyn Paz

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10 August 2017

13

William J Murphy

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author name string

Ryan Flynn

1

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10 August 2017

Jessica L Allen

2

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10 August 2017

Kylie A Alexander

6

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10 August 2017

Ante Vulic

7

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10 August 2017

Jing Du

8

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10 August 2017

Jonathan C Poe

11

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10 August 2017

Raphael A Clynes

22

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10 August 2017

language of work or name

English

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publication date

7 April 2015

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10 August 2017

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10 August 2017

125

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10 August 2017

26

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10 August 2017

4085-4094

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Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Increased BCR responsiveness in B cells from patients with chronic GVHD.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

A new murine model for bronchiolitis obliterans post-bone marrow transplant

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Transplantation's greatest challenges: advances in chronic graft-versus-host disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Toward biomarkers for chronic graft-versus-host disease: National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: III. Biomarker Working Group Report

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Syk is required for monocyte/macrophage chemotaxis to CX3CL1 (Fractalkine).

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Blockade of Syk ameliorates the development of murine sclerodermatous chronic graft-versus-host disease.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

An oral Syk kinase inhibitor in the treatment of rheumatoid arthritis: a three-month randomized, placebo-controlled, phase II study in patients with active rheumatoid arthritis that did not respond to biologic agents

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Anti-inflammatory actions of Syk inhibitors in macrophages involve non-specific inhibition of toll-like receptors-mediated JNK signaling pathway

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481596

Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines

6 December 2018

1 reference

12 December 2020

Close association between antibodies to cytoskeletal intermediate filaments, and chronic graft-versus-host disease

1 reference

12 December 2020

Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organ

1 reference

12 December 2020

B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation

1 reference

12 December 2020

Soluble receptor for advanced glycation end products triggers a proinflammatory cytokine cascade via beta2 integrin Mac-1

1 reference

12 December 2020

Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease

1 reference

12 December 2020

10.1182/BLOOD-2014-08-595470

Identifiers

DOI

1 reference

10 August 2017

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10 August 2017

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