Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology (Q35775018)

10 August 2017

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title

Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology (English)

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10 August 2017

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Erik I Christensen

1

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PubMed ID

15146321

10 August 2017

Jakub Gburek

series ordinal

2

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10 August 2017

14 May 2004

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10 August 2017

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10 August 2017

19

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10 August 2017

7

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10 August 2017

714-721

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https://scigraph.springernature.com/pub.10.1007/s00467-004-1494-0

10 August 2017

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Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

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Slow going for blood substitutes

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Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule

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Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis.

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Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome

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Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins

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Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

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Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

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12 December 2020

Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule

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Chronic progression of tubulointerstitial damage in proteinuric renal disease is mediated by complement activation: a therapeutic role for complement inhibitors?

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Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

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Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia

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Molecular Dissection of the Intrinsic Factor-Vitamin B12Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding

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Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney.

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Uptake and intracellular distribution of ferritin in the rat distal convoluted tubule

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The Adaptor Protein ARH Escorts Megalin to and through Endosomes

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Defective forebrain development in mice lacking gp330/megalin

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Multiple myeloma and renal failure

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Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor

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Effect of low molecular weight proteins and dextran on renal cathepsin B and L activity

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Myeloma light chains are ligands for cubilin (gp280).

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Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1

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Natural catalytic antibodies: peptide-hydrolyzing activities of Bence Jones proteins and VL fragment

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Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer

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Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney

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12 December 2020

Identification of an apical sorting determinant in the cytoplasmic tail of megalin

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Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin

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12 December 2020

Kappa light chain-associated Fanconi's syndrome: molecular analysis of monoclonal immunoglobulin light chains from patients with and without intracellular crystals

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12 December 2020

Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein

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12 December 2020

Expression of podocyte-associated molecules in acquired human kidney diseases

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12 December 2020

Intra-renal and subcellular distribution of the human chloride channel, CLC-5, reveals a pathophysiological basis for Dent's disease

1 reference

12 December 2020

Megalin knockout mice as an animal model of low molecular weight proteinuria.

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12 December 2020

ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells

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12 December 2020

Activation of mitogenic pathways by albumin in kidney proximal tubule epithelial cells: implications for the pathophysiology of proteinuric states

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X-linked hypercalciuric nephrolithiasis: clinical syndromes and chloride channel mutations

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12 December 2020

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein

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12 December 2020

Proteinuria and phenotypic change of proximal tubular cells

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12 December 2020

Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor

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12 December 2020

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

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12 December 2020

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12 December 2020

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12 December 2020

Physiological importance of endosomal acidification: potential role in proximal tubulopathies

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12 December 2020

Selective vitamin B12 malabsorption and proteinuria in young people. A syndrome.

1 reference

12 December 2020

Evidence for an essential role of megalin in transepithelial transport of retinol

1 reference

12 December 2020

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction

1 reference

12 December 2020

The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

1 reference

12 December 2020

New aspects of the pathogenesis of cystinosis.

1 reference

12 December 2020

Idiopathic chronic megaloblastic anemia in children

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12 December 2020

The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.

1 reference

12 December 2020

Globotriaosylceramide accumulation in the Fabry kidney is cleared from multiple cell types after enzyme replacement therapy

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12 December 2020

Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin

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12 December 2020

Proteinuria as a mediator of tubulointerstitial injury

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12 December 2020

OCCURRENCE OF PHAGOSOMES AND PHAGO-LYSOSOMES IN DIFFERENT SEGMENTS OF THE NEPHRON IN RELATION TO THE REABSORPTION, TRANSPORT, DIGESTION, AND EXTRUSION OF INTRAVENOUSLY INJECTED HORSERADISH PEROXIDASE

1 reference

12 December 2020

Lowe syndrome, a deficiency of phosphatidylinositol 4,5-bisphosphate 5-phosphatase in the Golgi apparatus

1 reference

12 December 2020

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

1 reference

12 December 2020

The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain

1 reference

12 December 2020

Genetic evidence of an accessory activity required specifically for cubilin brush-border expression and intrinsic factor-cobalamin absorption

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12 December 2020

Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis

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12 December 2020

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

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12 December 2020

Cd-MT causes endocytosis of brush-border transporters in rat renal proximal tubules

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12 December 2020

Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).

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12 December 2020

Effect of molecular charge on endocytic uptake of ferritin in renal proximal tubule cells

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12 December 2020

10.1007/S00467-004-1494-0

Identifiers

DOI

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10 August 2017

1 reference

PubMed ID

15146321