The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators (Q35774227)

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scientific article published on 14 September 2015

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English	The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators	scientific article published on 14 September 2015

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scholarly article

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Europe PubMed Central

10 August 2017

The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators (English)

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Europe PubMed Central

10 August 2017

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author name string

Magnus Gram

1

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Europe PubMed Central

10 August 2017

Ulrik Dolberg Anderson

2

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Europe PubMed Central

10 August 2017

Maria E Johansson

3

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Europe PubMed Central

10 August 2017

Anneli Edström-Hägerwall

4

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Europe PubMed Central

10 August 2017

Irene Larsson

5

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Europe PubMed Central

10 August 2017

Maya Jälmby

6

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Europe PubMed Central

10 August 2017

Stefan R Hansson

7

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Europe PubMed Central

10 August 2017

Bo Åkerström

8

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Europe PubMed Central

10 August 2017

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publication date

14 September 2015

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Europe PubMed Central

10 August 2017

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Europe PubMed Central

10 August 2017

10

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Europe PubMed Central

10 August 2017

e0138111

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Europe PubMed Central

10 August 2017

9

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Europe PubMed Central

10 August 2017

copyright license

Creative Commons Attribution 4.0 International

14 September 2015

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April 2022 Public Data File from Crossref

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Oxidative stress in preeclampsia and the role of free fetal hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Preeclampsia from a renal point of view: Insides into disease models, biomarkers and therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Pre-eclampsia and cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Fetal hemoglobin in preeclampsia: a new causative factor, a tool for prediction/diagnosis and a potential target for therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Angiogenic factors in diagnosis, management, and research in preeclampsia

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemopexin activity is associated with angiotensin II responsiveness in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Plasma hemopexin as a potential regulator of vascular responsiveness to angiotensin II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Pathological conditions involving extracellular hemoglobin: molecular mechanisms, clinical significance, and novel therapeutic opportunities for α(1)-microglobulin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Review: Biochemical markers to predict preeclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Up-regulation of A1M/α1-microglobulin in skin by heme and reactive oxygen species gives protection from oxidative damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Haptoglobin: old protein with new functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

The global impact of pre-eclampsia and eclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

The two stage model of preeclampsia: variations on the theme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

The lipocalin alpha1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Carbon monoxide, reactive oxygen signaling, and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Free radical metabolism in human erythrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Placental expression profiling in preeclampsia: local overproduction of hemoglobin may drive pathological changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Preeclampsia and future cardiovascular risk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Dual in vitro perfusion of an isolated cotyledon as a model to study the implication of changes in the third trimester placenta on preeclampsia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemoglobin and heme scavenging.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Latest advances in understanding preeclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Redox properties of the lipocalin alpha1-microglobulin: reduction of cytochrome c, hemoglobin, and free iron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Processing of the lipocalin alpha(1)-microglobulin by hemoglobin induces heme-binding and heme-degradation properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemopexin: a review of biological aspects and the role in laboratory medicine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Identification of the haemoglobin scavenger receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Hemoglobin autooxidation/oxidation mechanisms and methemoglobin prevention or reduction processes in the bloodstream. Literature review and outline of autooxidation reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

The pathogenetic role of heme in pregnancy-induced hypertension-like disease in ewes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

The heme oxygenase system: a regulator of second messenger gases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Formation of the alpha 1-microglobulin chromophore in mammalian and insect cells: a novel post-translational mechanism?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Microsomal heme oxygenase. Characterization of the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Partial purification and reconstitution of the heme oxygenase system from pig spleen microsomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Pregnancy-induced hypertension: development of a model in the pregnant sheep

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

On the mechanism of the chemical and enzymic oxygenations of alpha-oxyprotohemin IX to Fe.biliverdin IX alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Bilirubin is an antioxidant of possible physiological importance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Relationships Between β2-Microglobulin and Alloantigens Coded for by the Major Histocompatibility Complexes of the Rabbit and the Guinea Pig

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

12 July 2018

Carbon monoxide promotes proliferation of uterine natural killer cells and remodeling of spiral arteries in pregnant hypertensive heme oxygenase-1 mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Extracellular fetal hemoglobin induces increases in glomerular permeability: inhibition with α1-microglobulin and tempol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Endothelin-1 induces endoplasmic reticulum stress by activating the PLC-IP(3) pathway: implications for placental pathophysiology in preeclampsia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Increased levels of cell-free hemoglobin, oxidation markers, and the antioxidative heme scavenger alpha(1)-microglobulin in preeclampsia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Vascular contraction and preeclampsia: downregulation of the Angiotensin receptor 1 by hemopexin in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

The lipocalin alpha1-microglobulin has radical scavenging activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Identification of the receptor scavenging hemopexin-heme complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

The lipocalin alpha(1)-microglobulin binds heme in different species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Heme-scavenging role of alpha1-microglobulin in chronic ulcers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4569570

25 September 2018

Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0138111

21 January 2018

Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative reactions of hemoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant defence of red blood cells and plasma in stored human blood

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemopexin metabolism in patients with altered serum levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haptoglobin polymorphism affects nitric oxide bioavailability in preeclampsia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1-microglobulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Effect of p-Hydroxymercuribenzoate on the Reactions of the Isolated γ Chains of Human Hemoglobin with Ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the product of heme degradation catalyzed by the heme oxygenase system as biliverdin IX alpha by reversed-phase high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and properties of γ chain from human fetal hemoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pre-eclampsia: proteinuria in pre-eclampsia-does it matter any more?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fetal hemoglobin and α1-microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of biliverdin reductase from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/26368565

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0138111

1 reference

Europe PubMed Central

10 August 2017

2015PLoSO..1038111G

0 references

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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