Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough (Q35751844)

10 August 2017

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title

Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough (English)

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10 August 2017

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1

Anthony E Lang

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10 August 2017

Jose A Obeso

2

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PubMed ID

15099546

10 August 2017

language of work or name

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1 May 2004

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10 August 2017

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10 August 2017

3

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10 August 2017

5

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10 August 2017

309-316

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Neuroscience. Versatile cells against intractable diseases

10 August 2017

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From transplants to gene therapy for Parkinson's disease

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Dopaminergic cells of the carotid body: physiological significance and possible therapeutic applications in Parkinson's disease.

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Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

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Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

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Prospects for gene therapy in Parkinson's disease

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Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration.

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"On-off" effects in patients with Parkinson's disease on chronic levodopa therapy

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Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature

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The occurrence of depression in Parkinson's disease. A community-based study.

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Clinical and [18F] dopa PET findings in early Parkinson's disease

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Relationship between the appearance of symptoms and the level of nigrostriatal degeneration in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease.

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Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry

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Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

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Compensations after lesions of central dopaminergic neurons: some clinical and basic implications

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An [18F]dopa-PET and clinical study of the rate of progression in Parkinson's disease.

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[123I]beta-CIT SPECT imaging assessment of the rate of Parkinson's disease progression

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Pathophysiology of the basal ganglia in Parkinson's disease.

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Evolution of changes in neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra assessed by metabolic and electrophysiological measurements

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Upregulation of striatal preproenkephalin gene expression occurs before the appearance of parkinsonian signs in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine monkeys

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Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease

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Plasticity of the nigropallidal pathway in Parkinson's disease.

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Dopaminergic innervation of human basal ganglia

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Glutamate and Parkinson's disease

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Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection.

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Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: behavioural and immunohistochemical studies

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Subthalamic GAD gene therapy in a Parkinson's disease rat model

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Protection against dopaminergic nigrostriatal cell death by excitatory input ablation

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Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe

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Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease

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Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease

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The anterior olfactory nucleus in Parkinson's disease

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Neural transplantation for the treatment of Parkinson's disease

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Cell therapy in Parkinson's disease - stop or go?

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Neural transplantation: a hope for patients with Parkinson's disease

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Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

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Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease

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Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease

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Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

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Transplantation of embryonic dopamine neurons for severe Parkinson's disease

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A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease

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Dyskinesias following neural transplantation in Parkinson's disease.

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7 January 2021

Stem cells in the treatment of Parkinson's disease.

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7 January 2021

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

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Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases

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7 January 2021

10.1016/S1474-4422(04)00740-9

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15099546