A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity. (Q35747230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22101015%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity (English)

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17 January 2020

5

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17 January 2020

7

Ira Pastan

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17 January 2020

6

Byungkook Lee

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17 January 2020

2

Masanori Onda

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17 January 2020

author name string

Wenhai Liu

series ordinal

1

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17 January 2020

Changhoon Kim

series ordinal

3

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17 January 2020

Laiman Xiang

series ordinal

4

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17 January 2020

publication date

17 November 2011

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Protein Engineering Design and Selection

17 January 2020

published in

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17 January 2020

volume

25

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17 January 2020

page(s)

1-6

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17 January 2020

issue

1

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A recombinant immunotoxin targeting CD22 with low immunogenicity, low nonspecific toxicity, and high antitumor activity in mice.

17 January 2020

cites work

1 reference

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Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial

12 July 2018

1 reference

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Computer-aided design of functional protein interactions

12 July 2018

1 reference

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A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity.

12 July 2018

1 reference

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An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

12 July 2018

1 reference

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Immunotoxin treatment of cancer

12 July 2018

1 reference

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Enhancing immunogenicity by limiting susceptibility to lysosomal proteolysis

12 July 2018

1 reference

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Engineering of therapeutic antibodies to minimize immunogenicity and optimize function

12 July 2018

1 reference

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Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE.

12 July 2018

1 reference

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Recombinant immunotoxins in the treatment of cancer

12 July 2018

1 reference

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Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia

12 July 2018

1 reference

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Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies

12 July 2018

1 reference

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Disulfide bonds and protein folding.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276307

DT388-GM-CSF, a novel fusion toxin consisting of a truncated diphtheria toxin fused to human granulocyte-macrophage colony-stimulating factor, prolongs host survival in a SCID mouse model of acute myeloid leukemia

12 July 2018

1 reference

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Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276307

Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli.

12 July 2018

1 reference

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Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276307

Conformational stability of globular proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276307

A precise method for the determination of whole blood and plasma sulfhydryl groups

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3276307

Characterization of variant diphtheria toxin-interleukin-3 fusion protein, DTIL3K116W, for phase I clinical trials

12 July 2018

1 reference

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The effect of additional disulfide bonds on the stability and folding of ribonuclease A.

25 September 2018

1 reference

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Immunotoxin therapy of cancer

25 September 2018

1 reference

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Trypsin cleaves exclusively C-terminal to arginine and lysine residues

25 September 2018

1 reference

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Computer-aided design of a PDZ domain to recognize new target sequences.

25 September 2018

1 reference

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Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias

25 September 2018

1 reference

12 December 2020

Phase III placebo-controlled trial of denileukin diftitox for patients with cutaneous T-cell lymphoma

1 reference

12 December 2020

Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunosorbent assay

1 reference

12 December 2020

Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers

1 reference

12 December 2020

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

1 reference

12 December 2020

Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies

1 reference

12 December 2020

A nonradioactive, cell-free method for measuring protein synthesis inhibition by Pseudomonas exotoxin

1 reference

12 December 2020

Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients

1 reference

12 December 2020

Identifiers

DOI

10.1093/PROTEIN/GZR053

1 reference

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17 January 2020

1 reference

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17 January 2020

1 reference