Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis (Q35694436)

9 August 2017

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title

Sclerostin inhibition: a novel therapeutic approach in the treatment of osteoporosis (English)

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9 August 2017

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2

Dolores Shoback

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9 August 2017

Arti D Shah

1

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9 August 2017

E Michael Lewiecki

series ordinal

3

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9 August 2017

language of work or name

English

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publication date

2 June 2015

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International Journal of Women's Health

9 August 2017

published in

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9 August 2017

volume

7

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9 August 2017

page(s)

565-580

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Creative Commons Attribution-NonCommercial 3.0 Unported

9 August 2017

copyright license

start time

1 June 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density

12 July 2018

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Estimating prevalence of osteoporosis: examples from industrialized countries

12 July 2018

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Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome

12 July 2018

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Parathyroid hormone and parathyroid hormone-related protein analogs as therapies for osteoporosis

12 July 2018

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Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling

12 July 2018

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Systemic administration of sclerostin antibody enhances bone repair in a critical-sized femoral defect in a rat model.

12 July 2018

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Mutations in WNT1 cause different forms of bone fragility

12 July 2018

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Regulation of Wnt/β-catenin signaling within and from osteocytes

12 July 2018

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WNT signaling in bone homeostasis and disease: from human mutations to treatments

12 July 2018

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Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

12 July 2018

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The US postmarketing surveillance study of adult osteosarcoma and teriparatide: study design and findings from the first 7 years.

12 July 2018

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Sclerostin: therapeutic horizons based upon its actions

12 July 2018

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Anti-sclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats

12 July 2018

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Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading.

12 July 2018

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High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes

12 July 2018

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Osteoporosis: now and the future

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Sclerostin is a locally acting regulator of late-osteoblast/preosteocyte differentiation and regulates mineralization through a MEPE-ASARM-dependent mechanism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

An estimate of the worldwide prevalence and disability associated with osteoporotic fractures

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Clinical and molecular findings in osteoporosis-pseudoglioma syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Bone mineral density in sclerosteosis; affected individuals and gene carriers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Osteoporosis prevention, diagnosis, and therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Localization of the gene for sclerosteosis to the van Buchem disease-gene region on chromosome 17q12-q21

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Van Buchem disease (hyperostosis corticalis generalisata) maps to chromosome 17q12-q21.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Progressive increases in bone mass and bone strength in an ovariectomized rat model of osteoporosis after 26 weeks of treatment with a sclerostin antibody

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Tissue-level mechanisms responsible for the increase in bone formation and bone volume by sclerostin antibody

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Evaluation of the effects of systemic treatment with a sclerostin neutralizing antibody on bone repair in a rat femoral defect model.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Romosozumab in postmenopausal women with low bone mineral density.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Expression of sclerostin scFv and the effect of sclerostin scFv on healing of osteoporotic femur fracture in rats.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Time-dependent effects of sclerostin antibody on a mouse fracture healing model

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Van Buchem disease: clinical, biochemical, and densitometric features of patients and disease carriers

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Treatment with a sclerostin antibody increases cancellous bone formation and bone mass regardless of marrow composition in adult female rats.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Patients with sclerosteosis and disease carriers: human models of the effect of sclerostin on bone turnover

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459616

Update on romosozumab : a humanized monoclonal antibody to sclerostin

15 November 2018

1 reference

12 December 2020

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

1 reference

12 December 2020

Safety of osteoanabolic therapy: a decade of experience

1 reference

12 December 2020

Wnt signaling and the regulation of bone mass

1 reference

12 December 2020

Single- and Multiple-Dose Randomized Studies of Blosozumab, a Monoclonal Antibody Against Sclerostin, in Healthy Postmenopausal Women

1 reference

12 December 2020

Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

1 reference

12 December 2020

Sclerostin inhibition for osteoporosis--a new approach

1 reference

12 December 2020

Bone matrix quality after sclerostin antibody treatment

1 reference

12 December 2020

Wnt signaling as a therapeutic target for bone diseases

1 reference

12 December 2020

Increased bone formation and bone mass induced by sclerostin antibody is not affected by pretreatment or cotreatment with alendronate in osteopenic, ovariectomized rats

1 reference

12 December 2020

Identifiers

DOI

10.2147/IJWH.S73244

1 reference

9 August 2017

1 reference

9 August 2017

1 reference