Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants. (Q35689341)

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scientific article published on 21 November 2006

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English	Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants.	scientific article published on 21 November 2006

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22 December 2019

Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants (English)

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22 December 2019

Michael W Russell

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22 December 2019

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Hesham F Nawar

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22 December 2019

Sergio Arce

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22 December 2019

Terry D Connell

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22 December 2019

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21 November 2006

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22 December 2019

Infection and Immunity

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22 December 2019

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22 December 2019

2

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22 December 2019

621-633

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22 December 2019

Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: applications for oral infections

1 reference

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Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract

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Nontoxic Shiga toxin derivatives from Escherichia coli possess adjuvant activity for the augmentation of antigen-specific immune responses via dendritic cell activation

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12 July 2018

Differential binding of Escherichia coli enterotoxins LT-IIa and LT-IIb and of cholera toxin elicits differences in apoptosis, proliferation, and activation of lymphoid cells.

1 reference

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12 July 2018

Mucosal adjuvants

1 reference

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12 July 2018

Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities

1 reference

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12 July 2018

The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.

1 reference

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Modulation of the immune response by the cholera-like enterotoxins

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Recent developments in mucosal immunomodulatory adjuvants

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A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants

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Targeting of nasal mucosa-associated antigen-presenting cells in vivo with an outer membrane protein A derived from Klebsiella pneumoniae

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Distinct cytokine regulation by cholera toxin and type II heat-labile toxins involves differential regulation of CD40 ligand on CD4(+) T cells.

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12 July 2018

Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants.

1 reference

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12 July 2018

Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent costimulation of CD4(+) T cells

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Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues

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12 July 2018

Comparative analysis of the mucosal adjuvanticity of the type II heat-labile enterotoxins LT-IIa and LT-IIb

1 reference

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12 July 2018

Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins

1 reference

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12 July 2018

Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic

1 reference

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12 July 2018

Immunostimulatory activity of LT-IIa, a type II heat-labile enterotoxin of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1828530

12 July 2018

Biodegradable polymer microspheres as vaccine adjuvants and delivery systems

1 reference

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12 July 2018

Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin

1 reference

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12 July 2018

Modulation of B-cell activation by the B subunit of Escherichia coli enterotoxin: receptor interaction up-regulates MHC class II, B7, CD40, CD25 and ICAM-1.

1 reference

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Development of antibody-secreting cells and antigen-specific T cells in cervical lymph nodes after intranasal immunization

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12 July 2018

Crystal structure of a new heat-labile enterotoxin, LT-IIb

1 reference

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12 July 2018

Tolerance, danger, and the extended family

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Molecules involved in T-cell costimulation

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Protein antigens of Streptococcus mutans: purification and properties of a double antigen and its protease-resistant component.

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12 July 2018

New chemical trends in ganglioside research

1 reference

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12 July 2018

Production of type II heat-labile enterotoxin by Escherichia coli isolated from food and human feces.

1 reference

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Comparison of the carbohydrate-binding specificities of cholera toxin and Escherichia coli heat-labile enterotoxins LTh-I, LT-IIa, and LT-IIb

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Variation in chemical properties and antigenic determinants among type II heat-labile enterotoxins of Escherichia coli

1 reference

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12 July 2018

Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site-directed mutagenesis

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1 reference

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25 September 2018

The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.

1 reference

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25 September 2018

Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1828530

25 September 2018

Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli.

1 reference

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25 September 2018

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1 reference

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1 reference

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25 September 2018

Mutational analysis of the ganglioside-binding activity of the type II Escherichia coli heat-labile enterotoxin LT-IIb.

1 reference

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Peripheral deletion of antigen-reactive T cells in oral tolerance.

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25 September 2018

Monophosphoryl lipid A enhances mucosal and systemic immunity to vaccine antigens following intranasal administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118982

12 December 2020

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Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118982

12 December 2020

based on heuristic

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Intranasal immunisation with influenza-ISCOM induces strong mucosal as well as systemic antibody and cytotoxic T-lymphocyte responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118982

12 December 2020

based on heuristic

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The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118982

12 December 2020

based on heuristic

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Role of B cell stimulatory factor 1/interleukin 4 in clonal proliferation of B cells

1 reference

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12 December 2020

based on heuristic

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Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1 reference

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12 December 2020

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Clonal anergy is a potent mechanism of oral tolerance in the suppression of acute antigen-induced arthritis in rats by oral administration of the inducing antigen

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118982

12 December 2020

based on heuristic

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Mutational analysis of the role of ADP-ribosylation activity and GM1-binding activity in the adjuvant properties of the Escherichia coli heat-labile enterotoxin towards intranasally administered keyhole limpet hemocyanin

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholera toxin and related enterotoxins as potent immune modulators

1 reference

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inferred from PubMed ID database lookup

Mucosal adjuvants

1 reference

https://pubmed.ncbi.nlm.nih.gov/17118982

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1128/IAI.01009-06

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118982%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118982%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17118982%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

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