The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo (Q35687102)

9 August 2017

title

The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo (English)

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9 August 2017

7

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N Edison

1

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9 August 2017

D Zuri

2

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9 August 2017

I Maniv

3

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B Bornstein

4

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9 August 2017

T Lev

5

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Y Gottfried

6

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M Garcia-Fernandez

8

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J Kagan

9

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S Larisch

10

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publication date

26 August 2011

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Cell Death & Differentiation

9 August 2017

published in

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9 August 2017

volume

19

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9 August 2017

issue

2

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9 August 2017

page(s)

356-368

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https://scigraph.springernature.com/pub.10.1038/cdd.2011.112

9 August 2017

exact match

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cites work

ARTS and Siah collaborate in a pathway for XIAP degradation

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Sept4/ARTS is required for stem cell apoptosis and tumor suppression

12 July 2018

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Mitochondria and cell death: outer membrane permeabilization and beyond

12 July 2018

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Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis

12 July 2018

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XIAP discriminates between type I and type II FAS-induced apoptosis

12 July 2018

1 reference

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

12 July 2018

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12 July 2018

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Regulation of apoptosis by XIAP ubiquitin-ligase activity

12 July 2018

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Bid truncation mediated by caspases-3 and -9 in vinorelbine-induced apoptosis

12 July 2018

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Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein

12 July 2018

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Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration

12 July 2018

1 reference

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Which came first, the cytochrome c release or the mitochondrial fission?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Mechanisms of cytochrome c release from mitochondria

12 July 2018

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Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function

12 July 2018

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Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm).

12 July 2018

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Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

The Sept4 septin locus is required for sperm terminal differentiation in mice

12 July 2018

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Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

The pathophysiology of mitochondrial cell death

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

The mitochondrial ARTS protein promotes apoptosis through targeting XIAP

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis

12 July 2018

1 reference

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IAP proteins: blocking the road to death's door

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Generation and characterization of Smac/DIABLO-deficient mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Mechanisms of caspase activation and inhibition during apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Caspase-9 and APAF-1 form an active holoenzyme

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

X-linked IAP is a direct inhibitor of cell-death proteases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Expression of Bcl-x(S) in Xenopus oocytes induces BH3-dependent and caspase-dependent cytochrome c release and apoptosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263492

Inhibitors of apoptosis catch ubiquitin: Figure 1

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2011.112

21 January 2018

Identifiers

DOI

10.1038/CDD.2011.112

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Dimensions Publication ID

9 August 2017

0 references

1 reference

9 August 2017

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