A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors. (Q35687072)

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scientific article published on 5 June 2015

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English	A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors.	scientific article published on 5 June 2015

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16 February 2020

A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors (English)

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16 February 2020

neoplastic stem cells

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1

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16 February 2020

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Rupali A Gadkari

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16 February 2020

Satthenapalli V Ramakanth

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16 February 2020

Krishnanand Padmanabhan

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16 February 2020

Davanam S Madhumathi

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16 February 2020

Lakshmi Devi

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16 February 2020

Lingappa Appaji

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16 February 2020

Jon C Aster

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16 February 2020

Annapoorni Rangarajan

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16 February 2020

Rajan R Dighe

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5 June 2015

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16 February 2020

Scientific Reports

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16 February 2020

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16 February 2020

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16 February 2020

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Creative Commons Attribution 4.0 International

5 June 2015

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0 references

Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma.

1 reference

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27 July 2018

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer

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27 July 2018

Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness.

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27 July 2018

Specific inhibition of Notch1 signaling enhances the antitumor efficacy of chemotherapy in triple negative breast cancer through reduction of cancer stem cells

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27 July 2018

The Notch signalling system: recent insights into the complexity of a conserved pathway

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27 July 2018

A restricted cell population propagates glioblastoma growth after chemotherapy

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27 July 2018

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches

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27 July 2018

Targeting the Notch pathway: twists and turns on the road to rational therapeutics

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27 July 2018

Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors

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27 July 2018

Notch and disease: a growing field

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27 July 2018

Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

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27 July 2018

A monoclonal antibody against human Notch1 ligand-binding domain depletes subpopulation of putative breast cancer stem-like cells

1 reference

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27 July 2018

Docking and free energy simulations to predict conformational domains involved in hCG-LH receptor interactions using recombinant antibodies

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27 July 2018

Transcription factors that mediate epithelial-mesenchymal transition lead to multidrug resistance by upregulating ABC transporters.

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27 July 2018

Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

1 reference

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27 July 2018

Notch signaling in solid tumors.

1 reference

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27 July 2018

Targeting Notch signaling pathway to overcome drug resistance for cancer therapy

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27 July 2018

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

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27 July 2018

Targeting Notch to target cancer stem cells.

1 reference

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27 July 2018

Therapeutic antibody targeting of individual Notch receptors

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27 July 2018

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

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27 July 2018

Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis

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27 July 2018

The canonical Notch signaling pathway: unfolding the activation mechanism

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27 July 2018

HER-2, notch, and breast cancer stem cells: targeting an axis of evil

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27 July 2018

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

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27 July 2018

Rational targeting of Notch signaling in cancer

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27 July 2018

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

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27 July 2018

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

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27 July 2018

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

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27 July 2018

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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27 July 2018

Prospective identification of tumorigenic breast cancer cells

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27 July 2018

Comparative protein modelling by satisfaction of spatial restraints

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27 July 2018

Signalling downstream of activated mammalian Notch

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27 July 2018

Antibodies against the extracellular domain of human Notch1 receptor reveal the critical role of epidermal-growth-factor-like repeats 25-26 in ligand binding and receptor activation

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25 September 2018

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

1 reference

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25 September 2018

Phenotypic and functional characterization of human mammary stem/progenitor cells in long term culture.

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25 September 2018

Stem cells in mammary development and carcinogenesis: implications for prevention and treatment

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25 September 2018

Identification and expansion of human colon-cancer-initiating cells

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25 September 2018

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

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25 September 2018

Notch signaling in cancer

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25 September 2018

Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors

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12 December 2020

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Interaction interfaces of protein domains are not topologically equivalent across families within superfamilies: Implications for metabolic and signaling pathways

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SREP11012

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16 February 2020

1 reference

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16 February 2020

1 reference

Europe PubMed Central

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16 February 2020

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